LIN28A Products
(Lin-28 Homolog A (C. Elegans) (LIN28A))
Categories
Acts as a 'translational enhancer', driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in stabilizing the mRNAs. Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting an uridylyltransferase, leading to the terminal uridylation of pre- let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Specifically recognizes the 5'-GGAG-3' motif in the terminal loop of pre-let-7. Also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5'-GGAG-3' motif in the terminal loop, leading to their terminal uridylation and subsequent degradation (By similarity).
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Featured LIN28A Categories
LIN28A Antibodies
High quality antibodies with extensive validation data.
LIN28A ELISA Kits
Reliable ELISA kits for a wide range of species.
LIN28A Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended LIN28A Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse
Application
WB, IF, FACS, IHC (p)
Validations
- (6)
Cat. No.
ABIN655156
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, ICC
Validations
- (2)
- (3)
Cat. No.
ABIN968936
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Cow, Dog, Human, Pig, Sheep
Application
WB, IHC, IHC (p)
Validations
- (4)
Cat. No.
ABIN6741558
Quantity
100 μL
Datasheet
Datasheet
Recommended LIN28A ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6968296
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6957482
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6957483
Quantity
96 tests
Datasheet
Datasheet
Recommended LIN28A Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7123766
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN667750
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1309449
Quantity
25 μg
Datasheet
Datasheet
Latest Publications for our LIN28A products
: "Cancer stem-like cells can be induced through dedifferentiation under hypoxic conditions in glioma, hepatoma and lung cancer." in: Cell death discovery, Vol. 3, pp. 16105, (2017) (PubMed).: "A Rapid Induction Mechanism for Lin28a in Trophic Responses." in: Molecular cell, Vol. 65, Issue 3, pp. 490-503.e7, (2017) (PubMed).
: "Organoid models of human and mouse ductal pancreatic cancer. ..." in: Cell, Vol. 160, Issue 1-2, pp. 324-38, (2015) (PubMed).
: "Vascular gene expression and phenotypic correlation during differentiation of human embryonic stem cells." in: Developmental dynamics : an official publication of the American Association of Anatomists, Vol. 232, Issue 2, pp. 487-97, (2005) (PubMed).
: "Micro-RNA regulation of the mammalian lin-28 gene during neuronal differentiation of embryonal carcinoma cells." in: Molecular and cellular biology, Vol. 25, Issue 21, pp. 9198-208, (2005) (PubMed).
Synonyms and alternative names related to LIN28A
lin-28 homolog A (LIN28A), lin-28 homolog A (C. elegans) (Lin28a), lin-28 homolog A S homeolog (lin28a.S), lin-28 homolog A (C. elegans) (lin28a), lin-28 homolog A (Lin28a), lin-28 homolog A (lin28a), AL024421, CSDD1, csdd1, ENSMUSG00000070700, Gm10299, LIN-28, Lin-28, lin-28, lin-28A, LIN28, Lin28, lin28, RGD1566408, sb:cb650, Tex17, ZCCHC1, zcchc1, zgc:55584Protein level used designations for LIN28A
- RNA-binding protein LIN-28
- protein lin-28 homolog A
- zinc finger CCHC domain-containing protein 1
- zinc finger, CCHC domain containing 1
- testis expressed gene 17
- testis-expressed protein 17
- RNA-binding protein LIN-28A
- lin-28A
- RNA-binding protein lin-28
- Lin-28.1
- lin-28 homolog A (C. elegans)
- lin-28-like
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