ATPase, Ca++ Transporting, Type 2C, Member 1 (ATP2C1) (C-Term) antibody

Details for Product No. ABIN783438
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Antigen
Synonyms ATP2C1, ATP2C1A, BCPM, HHD, PMR1, SPCA1, hSPCA1, Spca1, si:dkey-11p23.6, SPCA, 1700121J11Rik, AW061228, D930003G21Rik, pmr1
Epitope
C-Term
(15), (7), (3), (2), (2), (2), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(49), (12), (8), (5), (1), (1), (1), (1), (1)
Host
Rabbit
(35), (15)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB)
(49), (29), (17), (5), (3), (2), (1), (1), (1), (1)
Pubmed 3 references available
Quantity 0.1 mg
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Catalog No. ABIN783438
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Immunogen 19 amino acid peptide near the carboxy terminus of human ATP2C1
Specificity This antibody detects ATP2C1 (C-term). At least four isoforms of ATP2C1 are known to exist, this antibody will recognize only the three longest isoforms. ATP2C1 antibody will not cross-react with ATP2C2. Species Reactivity: Tested: Human, mouse
Purification Affinity chromatography purified via peptide column
Alternative Name ATP2C1
Background ATP2C1, also known as secretory pathway Ca2+/Mn2+-ATPase (SPCA) 1, belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium from the cytosol to the Golgi lumen. Defects in this gene cause Hailey-Hailey disease, an autosomal dominant disorder characterized by persistent blisters and erosions of the skin. Unlike the related protein ATP2C2, ATP2C1 is ubiquitously expressed and displays a lower maximal turnover rate for overall Ca2+-ATPase reaction and a higher apparent affinity for cytosolic Ca2+ activation of phosphorylation. Recent evidence suggests that ATP2C1 is a key regulator of insulin-like growth factor receptor (IGF1R) processing in tumor progression in basal breast cancers.
Alternate names: ATP-dependent Calcium pump PMR1, ATPase 2C1, Calcium-transporting ATPase type 2C member 1, HUSSY-28, KIAA1347, PMR1L
Gene ID 27032
NCBI Accession NP_001001485
UniProt P98194
Research Area Signaling, Metabolism, Enzymes
Restrictions For Research Use only
Format Liquid
Buffer PBS containing 0.02% sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
Expiry Date 12 months
Background publications Hu, Bonifas, Beech et al.: "Mutations in ATP2C1, encoding a calcium pump, cause Hailey-Hailey disease." in: Nature genetics, Vol. 24, Issue 1, pp. 61-5, 2000 (PubMed).

Dode, Andersen, Vanoevelen et al.: "Dissection of the functional differences between human secretory pathway Ca2+/Mn2+-ATPase (SPCA) 1 and 2 isoenzymes by steady-state and transient kinetic analyses." in: The Journal of biological chemistry, Vol. 281, Issue 6, pp. 3182-9, 2006 (PubMed).

Grice, Vetter, Faddy et al.: "Golgi calcium pump secretory pathway calcium ATPase 1 (SPCA1) is a key regulator of insulin-like growth factor receptor (IGF1R) processing in the basal-like breast cancer cell line MDA-MB-231." in: The Journal of biological chemistry, Vol. 285, Issue 48, pp. 37458-66, 2010 (PubMed).

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