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TYW1 antibody (C-Term)

TYW1 Reactivity: Human, Rat WB, EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN783488
  • Target See all TYW1 Antibodies
    TYW1 (tRNA-YW Synthesizing Protein 1 Homolog (TYW1))
    Binding Specificity
    • 2
    • 2
    • 1
    C-Term
    Reactivity
    Human, Rat
    Host
    • 2
    • 2
    Rabbit
    Clonality
    • 3
    • 1
    Polyclonal
    Conjugate
    • 4
    This TYW1 antibody is un-conjugated
    Application
    • 4
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    Specificity
    This antibody detects TYW1 / RSAFD1 at C-term. TYW1 antibody is predicted to not cross-react with other TYW protein family members. At least three isoforms of TYW1 are known to exist, this antibody will only detect the two larger isoforms.
    Cross-Reactivity (Details)
    Species reactivity (tested):Human, rat
    Purification
    Affinity chromatography purified via peptide column
    Immunogen
    19 amino acid peptide near the carboxy terminus of human TYW1
    Top Product
    Discover our top product TYW1 Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.
  • Target
    TYW1 (tRNA-YW Synthesizing Protein 1 Homolog (TYW1))
    Alternative Name
    TYW1 / RSAFD1 (TYW1 Products)
    Synonyms
    RSAFD1 antibody, TYW1A antibody, YPL207W antibody, RGD1310420 antibody, Rsafd1 antibody, AW125391 antibody, im:6898509 antibody, wu:fb74d01 antibody, zgc:153368 antibody, tRNA-yW synthesizing protein 1 homolog (S. cerevisiae) antibody, S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase antibody, tRNA-yW synthesizing protein 1 homolog S homeolog antibody, tRNA-yW synthesizing protein 1 homolog antibody, TYW1 antibody, LOC100354908 antibody, tyw1.S antibody, Tyw1 antibody, tyw1 antibody
    Background
    TYW1, also known as TYW1A, RSAFD1 or YPL207W, is a 732 amino acid protein containing one flavodoxin-like domain that participates in the wybutosine-tRNA (Phe) biosynthesis pathway. Wybutosine (yW) is a hypermodified guanosine at the 3-prime position adjacent to the anticodon of phenylalanine tRNA that stabilizes codon-anticodon interactions during decoding on the ribosome. TYW1 is involved in a multistep enzymatic reaction that stabilizes codon-anticodon base-pairing during the ribosomal decoding process, thereby ensuring correct translation. TYW1 binds to one 4Fe-4S cluster and is located on human chromosome 7. Defects in some of the genes on chromosome 7 have been linked to Osteogenesis imperfecta, Williams-Beuren syndrome, Lissencephaly, Citrullinemia and Shwachman-Diamond syndrome, suggesting that TYW1 may play a role in these conditions.Synonyms: Radical S-adenosyl methionine and flavodoxin domain-containing protein 1, tRNA wybutosine-synthesizing protein 1 homolog, tRNA-yW-synthesizing protein
    Gene ID
    55253
    NCBI Accession
    NP_060734
    UniProt
    Q9NV66
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