CD209 Molecule (CD209) (AA 389-393) antibody

Details for Product No. ABIN871703
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Antigen
Synonyms cd209, CLEC4M, DC-SIGN, si:ch211-224h1.3, CDSIGN, CLEC4L, DC-SIGN1, CD209, CIRE, Dcsign, SIGN-R1, SIGNR5, Cd209
Epitope
AA 389-393
(24), (7), (7), (6), (4), (3), (3), (3), (2), (2), (2), (1), (1), (1)
Reactivity
Human
(221), (50), (13), (1)
Host
Rabbit
(127), (97), (51)
Clonality
Polyclonal
Conjugate
Un-conjugated
(35), (21), (19), (17), (16), (10), (8), (4), (3), (3), (3), (3), (3), (3), (1)
Application
Western Blotting (WB)
(154), (100), (37), (35), (33), (30), (29), (21), (15), (13), (6), (3), (3), (2), (1)
Pubmed 3 references available
Quantity 100 μL
Shipping to United States (Change)
Availability Will be delivered in 2 to 3 Business Days
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Catalog No. ABIN871703
220.00 $
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Immunogen Peptide sequence around AA 389-393 ( E-Q-F-L-S ) derived from Human CD209 (DC-SIGN) . Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
Specificity The antibody detects endogenous level of total CD209 (DC-SIGN) protein.
Purification Affinity purified
Alternative Name CD209 (DC-SIGN)
Background Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response. Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens, including HIV-1 gp120, HIV-2 gp120, SIV gp120, ebolavirus glycoproteins, cytomegalovirus gB, HCV E2, dengue virus gE, Leishmania pifanoi LPG, Lewis-x antigen in Helicobacter pylori LPS, mannose in Klebsiella pneumonae LPS, di-mannose and tri-mannose in Mycobacterium tuberculosis ManLAM and Lewis-x antigen in Schistosoma mansoni SEA. On DCs it is a high affinity receptor for ICAM2 and ICAM3 by binding to mannose-like carbohydrates. May act as a DC rolling receptor that mediates transendothelial migration of DC presursors from blood to tissues by binding endothelial ICAM2. Seems to regulate DC-induced T-cell proliferation by binding to ICAM3 on T-cells in the immunological synapse formed between DC and T-cells.
Molecular Weight 46 kDa
Gene ID 30835
NCBI Accession NP_066978
UniProt Q9NNX6
Application Notes Western blotting: 1:500-1:1000
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
Background publications Geijtenbeek, Kwon, Torensma et al.: "DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells." in: Cell, Vol. 100, Issue 5, pp. 587-97, 2000 (PubMed).

Geijtenbeek, Krooshoop, Bleijs et al.: "DC-SIGN-ICAM-2 interaction mediates dendritic cell trafficking." in: Nature immunology, Vol. 1, Issue 4, pp. 353-7, 2001 (PubMed).

Engering, Geijtenbeek, van Vliet et al.: "The dendritic cell-specific adhesion receptor DC-SIGN internalizes antigen for presentation to T cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 168, Issue 5, pp. 2118-26, 2002 (PubMed).

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