DC-SIGN/CD209 Products
(CD209)
Categories
This gene encodes a transmembrane receptor and is often referred to as DC-SIGN because of its expression on the surface of dendritic cells and macrophages. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are rare but have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 10332\; often referred to as L-SIGN). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.[provided by RefSeq, Feb 2009].
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Featured DC-SIGN/CD209 Categories
DC-SIGN/CD209 Antibodies
High quality antibodies with extensive validation data.
DC-SIGN/CD209 ELISA Kits
Reliable ELISA kits for a wide range of species.
DC-SIGN/CD209 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended DC-SIGN/CD209 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (7)
Cat. No.
ABIN7444307
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, FACS, IHC, ELISA, ICC, Neut
Validations
- (5)
Cat. No.
ABIN5611274
Quantity
0.1 mg
Datasheet
Datasheet
Reactivity
Human
Application
WB, FACS, IHC, IF, ISt, StM
Validations
- (5)
Cat. No.
ABIN6939610
Quantity
100 μg
Datasheet
Datasheet
Recommended DC-SIGN/CD209 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN5692223
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN4882572
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Chicken
Analytical Method
Validations
Cat. No.
ABIN1052934
Quantity
96 tests
Datasheet
Datasheet
Recommended DC-SIGN/CD209 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (3)
Cat. No.
ABIN7275586
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Human Cells
Validations
- (1)
Cat. No.
ABIN7319880
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1348573
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our DC-SIGN/CD209 products
: "Decreased demand for olfactory periglomerular cells impacts on neural precursor cell viability in the rostral migratory stream." in: Scientific reports, Vol. 6, pp. 32203, (2016) (PubMed).: "Dendritic cells from the human female reproductive tract rapidly capture and respond to HIV." in: Mucosal immunology, (2016) (PubMed).
: "HCV RNA Activates APCs via TLR7/TLR8 While Virus Selectively Stimulates Macrophages Without Inducing Antiviral Responses." in: Scientific reports, Vol. 6, pp. 29447, (2016) (PubMed).
: "Uukuniemi Virus as a Tick-Borne Virus Model." in: Journal of virology, Vol. 90, Issue 15, pp. 6784-98, (2016) (PubMed).
: "Protective effects of astaxanthin on ConA-induced autoimmune hepatitis by the JNK/p-JNK pathway-mediated inhibition of autophagy and apoptosis." in: PLoS ONE, Vol. 10, Issue 3, pp. e0120440, (2015) (PubMed).
: "Antibody-opsonized bacteria evoke an inflammatory dendritic cell phenotype and polyfunctional Th cells by cross-talk between TLRs and FcRs." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 194, Issue 4, pp. 1856-66, (2015) (PubMed).
: "Langerhans Cell-Dendritic Cell Cross-Talk via Langerin and Hyaluronic Acid Mediates Antigen Transfer and Cross-Presentation of HIV-1." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 195, Issue 4, pp. 1763-73, (2015) (PubMed).
: "Genome-wide small interfering RNA screens reveal VAMP3 as a novel host factor required for Uukuniemi virus late penetration." in: Journal of virology, Vol. 88, Issue 15, pp. 8565-78, (2014) (PubMed).
: "A novel pilot study of endometrial stromal cells and immune cell populations in sentinel uterine-draining lymph nodes during the menstrual cycle and in endometriosis." in: Reproductive sciences (Thousand Oaks, Calif.), Vol. 20, Issue 11, pp. 1339-48, (2013) (PubMed).
: "Comparative histology and immunohistochemistry of porcine versus human skin." in: European journal of dermatology : EJD, Vol. 23, Issue 4, pp. 456-66, (2013) (PubMed).
Synonyms and alternative names related to DC-SIGN/CD209
CD209 molecule (CD209), CD209 molecule (cd209), CD209a antigen (Cd209a), CD209 antigen-like protein D (LOC100529184), CD209c molecule (Cd209c), CD209 antigen (LOC100460708), CD209 antigen (LOC105484282), cd209, CD209, Cd209, CDSIGN, CIRE, CLEC4L, CLEC4M, DC-SIGN, DC-SIGN1, Dcsign, si:ch211-224h1.3, SIGN-R1, SIGNR5Protein level used designations for DC-SIGN/CD209
- C-type lectin domain family 4 member L
- C-type lectin domain family 4, member L
- CD209 antigen
- HIV gpl20-binding protein
- dendritic cell-specific ICAM-3-grabbing non-integrin 1
- dendritic cell-specific intracellular adhesion molecules (ICAM)-3 grabbing non-integrin
- CD209-like protein
- DC-SIGN1
- dendritic cell-specific ICAM-3 grabbing non-integrin
- C-type lectin domain family 4, member M
- DC-SIGN protein
- putative mannose-binding C-type lectin
- CD209 antigen-like protein A
- dendritic cell-specific ICAM-3-grabbing non-integrin
- CD209
- CD209 antigen-like protein C
- CD209c antigen
- Dendritic cell-specific ICAM-3-grabbing non-integrin 1
- dendritic cell-specific ICAM-3 grabbing nonintegrin
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