CD1a Molecule (CD1A) antibody

Details for Product No. ABIN94018
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Antigen
Synonyms CD1B, R4, T6, CD1, FCB6, HTA1, CD1A, CD1.1, CD1.2, CD1A2
Reactivity
Human
(209), (25), (24), (15), (10), (4)
Host
Mouse
(175), (69)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(24), (20), (17), (7), (7), (4), (4), (4), (3), (3), (3), (3), (3), (3), (3), (1), (1), (1), (1)
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Flow Cytometry (FACS)
(115), (56), (46), (44), (34), (30), (27), (19), (14), (6), (1), (1), (1)
Pubmed 10 references available
Catalog no. ABIN94018
Quantity 0.1 mg
Price
304.92 $   Plus shipping costs $45.00
Options
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  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen Human thymocytes
Clone HI149
Isotype IgG1
Specificity The antibody HI149 reacts with CD1a (T6), a 49 kDa polypeptide associated with beta2-microglobulin expressed on cortical thymocytes (strongly), Langerhans cells, dendritic cells and some T cell leukemias and lymphomas. The antibody does not react with peripheral blood T and B lymphocytes, monocytes, granulocytes, platelets and erythrocytes. HLDA V, WS Code CD01.01
Purification Purified by protein A
Purity > 95 % (by SDS-PAGE)
Alternative Name CD1A
Background CD1a, together with CD1b and c, belongs to group 1 of CD1 glycoproteins. These proteins serve as antigen-presenting molecules for a subset of T cells that responds to specific lipids and glycolipids found in the cell walls of bacterial pathogens or self-glycolipid antigens such as gangliosides, and they have also roles in antiviral immunity. Unlike CD1b, CD1a is excluded from late endosomal compartments and instead traffics independently in the recycling pathway of the early endocytic system, and CD1a antigen presentation is independent upon vesicular acidification.
Gene ID 1q22-q23
Application Notes Working concentrations should be determined by the investigator.I t is recommended that the user titrates the reagent for use in the particular testing system.

Working concentrations should be determined by the investigator.
Restrictions For Research Use only
Concentration 1 mg/mL
Buffer Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Handling Advice Do not freeze.
Storage 4 °C
Storage Comment Store at 2-8 °C. Do not use after expiration date stamped on vial label.
General Saeemann, Parolini, Boehmig et al.: "Bacterial metabolite interference with maturation of human monocyte-derived dendritic cells." in: Journal of leukocyte biology, Vol. 71, Issue 2, pp. 238-46, 2002 (PubMed).

Hunger, Sieling, Ochoa et al.: "Langerhans cells utilize CD1a and langerin to efficiently present nonpeptide antigens to T cells." in: The Journal of clinical investigation, Vol. 113, Issue 5, pp. 701-8, 2004 (PubMed).

McKenna, Asplund, Kroft: "Immunophenotypic analysis of hematogones (B-lymphocyte precursors) and neoplastic lymphoblasts by 4-color flow cytometry." in: Leukemia & lymphoma, Vol. 45, Issue 2, pp. 277-85, 2004 (PubMed).

Demedts, Brusselle, Vermaelen et al.: "Identification and characterization of human pulmonary dendritic cells." in: American journal of respiratory cell and molecular biology, Vol. 32, Issue 3, pp. 177-84, 2005 (PubMed).

Kirsch, Zeyda, Stuhlmeier et al.: "The active metabolite of leflunomide, A77 1726, interferes with dendritic cell function." in: Arthritis research & therapy, Vol. 7, Issue 3, pp. R694-703, 2005 (PubMed).

Chen, Murakami, Oppenheim et al.: "Triptolide, a constituent of immunosuppressive Chinese herbal medicine, is a potent suppressor of dendritic-cell maturation and trafficking." in: Blood, Vol. 106, Issue 7, pp. 2409-16, 2005 (PubMed).

Perros, Dorfmueller, Souza et al.: "Dendritic cell recruitment in lesions of human and experimental pulmonary hypertension." in: The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology, Vol. 29, Issue 3, pp. 462-8, 2007 (PubMed).

Angel, Lala, Chen et al.: "CD14+ antigen-presenting cells in human dermis are less mature than their CD1a+ counterparts." in: International immunology, Vol. 19, Issue 11, pp. 1271-9, 2007 (PubMed).

Favali, Tavares, Claruencio et al.: "Leishmania amazonensis infection impairs differentiation and function of human dendritic cells." in: Journal of leukocyte biology, Vol. 82, Issue 6, pp. 1401-6, 2007 (PubMed).

Mayer, Irschick, Moser et al.: "Characterization of antigen-presenting cells in fresh and cultured human corneas using novel dendritic cell markers." in: Investigative ophthalmology & visual science, Vol. 48, Issue 10, pp. 4459-67, 2007 (PubMed).

Hosts (175), (69)
Reactivities (209), (25), (24), (15), (10), (4)
Applications (115), (56), (46), (44), (34), (30), (27), (19), (14), (6), (1), (1), (1)
Conjugates (24), (20), (17), (7), (7), (4), (4), (4), (3), (3), (3), (3), (3), (3), (3), (1), (1), (1), (1)
Epitopes (8), (6), (3), (2), (2), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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