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Adenylate Cyclase 2 (Brain) (ADCY2) (AA 458-489), (Middle Region) antibody

Details for Product No. ABIN950278, Supplier: Login to see
Antigen
  • ADCY2
  • mKIAA1060
  • AC2
  • HBAC2
Alternatives
anti-Human Adenylate Cyclase 2 (Brain) antibody for Enzyme Immunoassay
Epitope
AA 458-489, Middle Region
5
5
3
2
2
2
2
2
1
1
1
1
1
1
Reactivity
Human
28
6
5
1
Host
Rabbit
26
3
Clonality
Polyclonal
Conjugate
Un-conjugated
1
1
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
24
12
4
4
3
3
2
2
1
1
1
1
Supplier
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Immunogen KLH conjugated synthetic peptide between 458-489 amino acids from the Central region of human ADCY2
Isotype Ig
Specificity This antibody reacts to Adenylate cyclase type 2.
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Saturated Ammonium Sulfate (SAS) precipitation
Alternative Name Adenylate Cyclase Type 2 (ADCY2 Antibody Abstract)
Background This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This enzyme is insensitive to Ca(2+)/calmodulin, and is stimulated by the G protein beta and gamma subunit complex.Synonyms: ADCY2, ATP pyrophosphate-lyase 2, Adenylate cyclase type II, Adenylyl cyclase 2, KIAA1060
Gene ID 108
NCBI Accession NP_065433
Pathways EGFR Signaling Pathway, Neurotrophin Signaling Pathway
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09 % (W/V) sodium azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Western Blotting (WB) image for anti-Adenylate Cyclase 2 (Brain) (ADCY2) (AA 458-489), (Middle Region) antibody (ABIN950278) ADCY2 Antibody (Center) western blot analysis in Jurkat cell line lysates (35 µg/lane...
Background publications Halls, Cooper: "Sub-picomolar relaxin signalling by a pre-assembled RXFP1, AKAP79, AC2, beta-arrestin 2, PDE4D3 complex." in: The EMBO journal, Vol. 29, Issue 16, pp. 2772-87, 2010 (PubMed).

Need, Keefe, Ge et al.: "Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis." in: European journal of human genetics : EJHG, Vol. 17, Issue 7, pp. 946-57, 2009 (PubMed).

Uhl, Liu, Drgon et al.: "Molecular genetics of successful smoking cessation: convergent genome-wide association study results." in: Archives of general psychiatry, Vol. 65, Issue 6, pp. 683-93, 2008 (PubMed).

Sunahara, Taussig: "Isoforms of mammalian adenylyl cyclase: multiplicities of signaling." in: Molecular interventions, Vol. 2, Issue 3, pp. 168-84, 2004 (PubMed).

Hanna, Kruskal, Ezekowitz et al.: "Role of macrophage oxidative burst in the action of anthrax lethal toxin." in: Molecular medicine (Cambridge, Mass.), Vol. 1, Issue 1, pp. 7-18, 1996 (PubMed).