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Adenylate Cyclase 2 (Brain) (ADCY2) (AA 458-489), (Middle Region) antibody

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Synonyms ADCY2, mKIAA1060, AC2, HBAC2
AA 458-489, Middle Region
(5), (5), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
(28), (6), (5), (1)
(26), (3)
(1), (1)
Enzyme Immunoassay (EIA), Western Blotting (WB)
(24), (12), (4), (4), (3), (3), (2), (2), (1), (1), (1), (1)
Pubmed 5 references available
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Quantity 0.4 mL
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Immunogen KLH conjugated synthetic peptide between 458-489 amino acids from the Central region of human ADCY2
Isotype Ig
Specificity This antibody reacts to Adenylate cyclase type 2.
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Saturated Ammonium Sulfate (SAS) precipitation
Alternative Name Adenylate Cyclase Type 2 (ADCY2 Antibody Abstract)
Background This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This enzyme is insensitive to Ca(2+)/calmodulin, and is stimulated by the G protein beta and gamma subunit complex.Synonyms: ADCY2, ATP pyrophosphate-lyase 2, Adenylate cyclase type II, Adenylyl cyclase 2, KIAA1060
Gene ID 108
NCBI Accession NP_065433
Pathways EGFR Signaling Pathway, Neurotrophin Signaling Pathway
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09 % (W/V) sodium azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Western Blotting (WB) image for anti-Adenylate Cyclase 2 (Brain) (ADCY2) (AA 458-489), (Middle Region) antibody (ABIN950278) ADCY2 Antibody (Center) western blot analysis in Jurkat cell line lysates (35 µg/lane...
Background publications Halls, Cooper: "Sub-picomolar relaxin signalling by a pre-assembled RXFP1, AKAP79, AC2, beta-arrestin 2, PDE4D3 complex." in: The EMBO journal, Vol. 29, Issue 16, pp. 2772-87, 2010 (PubMed).

Need, Keefe, Ge et al.: "Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis." in: European journal of human genetics : EJHG, Vol. 17, Issue 7, pp. 946-57, 2009 (PubMed).

Uhl, Liu, Drgon et al.: "Molecular genetics of successful smoking cessation: convergent genome-wide association study results." in: Archives of general psychiatry, Vol. 65, Issue 6, pp. 683-93, 2008 (PubMed).

Sunahara, Taussig: "Isoforms of mammalian adenylyl cyclase: multiplicities of signaling." in: Molecular interventions, Vol. 2, Issue 3, pp. 168-84, 2004 (PubMed).

Hanna, Kruskal, Ezekowitz et al.: "Role of macrophage oxidative burst in the action of anthrax lethal toxin." in: Molecular medicine (Cambridge, Mass.), Vol. 1, Issue 1, pp. 7-18, 1996 (PubMed).

Catalog No. ABIN950278
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