Adenosylhomocysteinase (AHCY) (N-Term), (AA 86-118) antibody

Details for Product No. ABIN950286
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Synonyms sahh, PSPTO5068, Ahcy, SAHH, adoHcyase, ahcy, AA987153, AL024110, CuBP, D150, cb1079, hm:zeh1173, hm:zeh1364, wu:fj67b02
N-Term, AA 86-118
(12), (11), (3), (2), (1)
Human, Mouse (Murine)
(61), (24), (17), (13), (13), (13), (12), (1), (1)
(50), (14)
(3), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1)
Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(53), (29), (12), (10), (9), (3), (2), (2), (2), (1), (1), (1)
Pubmed 4 references available
Quantity 0.4 mL
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Request Want additional data for this product?

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Catalog No. ABIN950286
357.50 $
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Immunogen KLH conjugated synthetic peptide between 86-118 amino acids from the N-terminal region of human AHCY
Isotype Ig
Specificity This antibody reacts to AdoHcyase.
Cross-Reactivity (Details) Species reactivity (tested):Mouse.
Purification Saturated Ammonium Sulfate (SAS) precipitation
Alternative Name AdoHcyase (AHCY)
Background S-adenosylhomocysteine hydrolase belongs to the adenosylhomocysteinase family. It catalyzes the reversible hydrolysis of S-adenosylhomocysteine (AdoHcy) to adenosine (Ado) and L-homocysteine (Hcy). Thus, it regulates the intracellular S-adenosylhomocysteine (SAH) concentration thought to be important for transmethylation reactions. Deficiency in this protein is one of the different causes of hypermethioninemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.Synonyms: Adenosylhomocysteinase, S-adenosyl-L-homocysteine hydrolase, SAHH
Gene ID 191
NCBI Accession NP_000678
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09 % (W/V) sodium azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Levine, Figueiredo, Lee et al.: "A candidate gene study of folate-associated one carbon metabolism genes and colorectal cancer risk." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 19, Issue 7, pp. 1812-21, 2010 (PubMed).

Giusti, Saracini, Bolli et al.: "Early-onset ischaemic stroke: analysis of 58 polymorphisms in 17 genes involved in methionine metabolism." in: Thrombosis and haemostasis, Vol. 104, Issue 2, pp. 231-42, 2010 (PubMed).

Joyce, Donald, Elder: "Individual differences in plasma cortisol changes during mania and depression." in: Journal of affective disorders, Vol. 12, Issue 1, pp. 1-5, 1987 (PubMed).

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