Adenosylhomocysteinase (AHCY) (N-Term), (AA 86-118) antibody

Details for Product No. ABIN950286
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Antigen
Synonyms SAHH, adoHcyase, AA987153, AL024110, CuBP, D150, cb1079, hm:zeh1173, hm:zeh1364, wu:fj67b02, sahh, PSPTO5068, Ahcy
Epitope
N-Term, AA 86-118
(8), (2), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(33), (19), (17), (13), (13), (13), (12), (1), (1)
Host
Rabbit
(31), (4)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(25), (13), (11), (10), (5), (2), (2), (1)
Pubmed 4 references available
Catalog no. ABIN950286
Quantity 0.4 mL
Price
357.50 $   Plus shipping costs $45.00
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Immunogen KLH conjugated synthetic peptide between 86-118 amino acids from the N-terminal region of human AHCY
Specificity This antibody reacts to AdoHcyase.
Purification Saturated Ammonium Sulfate (SAS) precipitation
Alternative Name AdoHcyase (AHCY)
Background S-adenosylhomocysteine hydrolase belongs to the adenosylhomocysteinase family. It catalyzes the reversible hydrolysis of S-adenosylhomocysteine (AdoHcy) to adenosine (Ado) and L-homocysteine (Hcy). Thus, it regulates the intracellular S- adenosylhomocysteine (SAH) concentration thought to be important for transmethylation reactions. Deficiency in this protein is one of the different causes of hypermethioninemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Alternate names: Adenosylhomocysteinase, S-adenosyl-L-homocysteine hydrolase, SAHH
Gene ID 191
NCBI Accession NP_000678
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09% (w/v) sodium azide as preservative
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Joyce, Donald, Elder: "Individual differences in plasma cortisol changes during mania and depression." in: Journal of affective disorders, Vol. 12, Issue 1, pp. 1-5, 1987 (PubMed).

Giusti, Saracini, Bolli et al.: "Early-onset ischaemic stroke: analysis of 58 polymorphisms in 17 genes involved in methionine metabolism." in: Thrombosis and haemostasis, Vol. 104, Issue 2, pp. 231-42, 2010 (PubMed).

Levine, Figueiredo, Lee et al.: "A candidate gene study of folate-associated one carbon metabolism genes and colorectal cancer risk." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 19, Issue 7, pp. 1812-21, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Hosts (31), (4)
Reactivities (33), (19), (17), (13), (13), (13), (12), (1), (1)
Applications (25), (13), (11), (10), (5), (2), (2), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (8), (2), (1), (1), (1)
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