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Arachidonate Lipoxygenase 3 (ALOXE3) (AA 230-260), (Middle Region) antibody

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Synonyms e-lox, elox3, ARCI3, E-LOX, eLOX3, e-LOX-3, ALOX15B
AA 230-260, Middle Region
(15), (13), (11), (4), (3), (2), (2), (2), (1)
Human, Mouse (Murine)
(52), (16), (13)
(49), (3)
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Enzyme Immunoassay (EIA), Western Blotting (WB)
(39), (23), (11), (10), (6), (1), (1)
Pubmed 4 references available
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Quantity 0.4 mL
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Immunogen KLH conjugated synthetic peptide between 230-260 amino acids from the Central region of human ALOXE3
Isotype Ig
Specificity This antibody reacts to ALOXE3.
Cross-Reactivity (Details) Species reactivity (tested):Human and Mouse.
Purification Affinity chromatography on Protein A
Alternative Name ALOXE3 (ALOXE3 Antibody Abstract)
Background ALOXE3 is a member of the lipoxygenase family, which are catabolized by arachidonic acid-derived compounds. The encoded enzyme is a hydroperoxide isomerase that synthesizes a unique type of epoxy alcohol (8R-hydroxy-11R,12R-epoxyeicosa-5Z,9E,14Z-trienoic acid) from 12R-hydroperoxyeicosatetraenoic acid (12R-HPETE). This epoxy alcohol can activate the the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha), which is implicated in epidermal differentiation. Loss of function of the enzyme encoded by this gene results in ichthyosis, implicating the function of this gene in the differentiation of human skin.Synonyms: Epidermis-type lipoxygenase 3, e-LOX-3, eLOX3
Gene ID 59344
NCBI Accession NP_001159432
Research Area Signaling, Metabolism
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09 % (W/V) sodium azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Western Blotting (WB) image for anti-Arachidonate Lipoxygenase 3 (ALOXE3) (AA 230-260), (Middle Region) antibody (ABIN950356) ALOXE3 Antibody (Center) western blot analysis in mouse kidney tissue lysates (35µg/l...
Background publications Han, Lan, Park et al.: "Polymorphisms in innate immunity genes and risk of childhood leukemia." in: Human immunology, Vol. 71, Issue 7, pp. 727-30, 2010 (PubMed).

Rajaraman, Brenner, Neta et al.: "Risk of meningioma and common variation in genes related to innate immunity." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 19, Issue 5, pp. 1356-61, 2010 (PubMed).

Vahlquist, Bygum, Gånemo et al.: "Genotypic and clinical spectrum of self-improving collodion ichthyosis: ALOX12B, ALOXE3, and TGM1 mutations in Scandinavian patients." in: The Journal of investigative dermatology, Vol. 130, Issue 2, pp. 438-43, 2010 (PubMed).

Rajaraman, Brenner, Butler et al.: "Common variation in genes related to innate immunity and risk of adult glioma." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 18, Issue 5, pp. 1651-8, 2009 (PubMed).

Catalog No. ABIN950356
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