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AMACR antibody (alpha-Methylacyl-CoA Racemase) (AA 330-359)

Details for Product anti-AMACR Antibody No. ABIN950388, Supplier: Log in to see
Antigen
  • AMACR
  • DKFZp469O1232
  • amacr
  • NCU04099.1
  • MGC89832
  • AMACRD
  • CBAS4
  • RACE
  • RM
  • Macr1
  • Da1-8
  • Marc1
Epitope
AA 330-359, C-Term
27
10
8
5
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
Reactivity
Human
151
35
34
Host
Rabbit
104
45
2
Clonality
Polyclonal
Conjugate
This AMACR antibody is un-conjugated
6
5
4
3
3
3
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
108
74
53
30
23
19
15
11
10
6
4
4
1
1
Supplier
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Immunogen KLH conjugated synthetic peptide between 330-359 amino acids from the C-terminal region of human AMACR
Isotype Ig
Specificity This antibody reacts to AMACR.
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Affinity chromatography on Protein A
Alternative Name AMACR / RACE (AMACR Antibody Abstract)
Background This gene encodes a racemase. The encoded enzyme interconverts pristanoyl-CoA and C27-bile acylCoAs between their (R)- and (S)-stereoisomers. The conversion to the (S)-stereoisomers is necessary for degradation of these substrates by peroxisomal beta-oxidation. Encoded proteins from this locus localize to both mitochondria and peroxisomes. Mutations in this gene may be associated with adult-onset sensorimotor neuropathy, pigmentary retinopathy, and adrenomyeloneuropathy due to defects in bile acid synthesis. Alternatively spliced transcript variants have been described.Synonyms: 2-methylacyl-CoA racemase, Alpha-methylacyl-CoA racemase, P504S
Gene ID 23600
NCBI Accession NP_055139
Pathways
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Flow Cytometry (FACS) image for anti-AMACR antibody (alpha-Methylacyl-CoA Racemase) (AA 330-359) (ABIN950388) AMACR Antibody (C-term) flow cytometric analysis of MDA-MB231 cells (right histogram)...
Immunofluorescence (IF) image for anti-AMACR antibody (alpha-Methylacyl-CoA Racemase) (AA 330-359) (ABIN950388) Confocal immunofluorescent analysis of AMACR Antibody (C-term) with HepG2 cell follow...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-AMACR antibody (alpha-Methylacyl-CoA Racemase) (AA 330-359) (ABIN950388) AMACR antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin ...
Western Blotting (WB) image for anti-AMACR antibody (alpha-Methylacyl-CoA Racemase) (AA 330-359) (ABIN950388) AMACR Antibody (C-term) western blot analysis in MDA-MB231 cell line lysates (35µg/la...
Background publications Murray, Calaf, Badinez et al.: "P504S expressing circulating prostate cells as a marker for prostate cancer." in: Oncology reports, Vol. 24, Issue 3, pp. 687-92, 2010 (PubMed).

Sonwalkar, Rotimi, Scott et al.: "A study of indefinite for dysplasia in Barrett's oesophagus: reproducibility of diagnosis, clinical outcomes and predicting progression with AMACR (alpha-methylacyl-CoA-racemase)." in: Histopathology, Vol. 56, Issue 7, pp. 900-7, 2010 (PubMed).

Lakis, Papamitsou, Panagiotopoulou et al.: "AMACR is associated with advanced pathologic risk factors in sporadic colorectal adenomas." in: World journal of gastroenterology : WJG, Vol. 16, Issue 20, pp. 2476-83, 2010 (PubMed).

Chen, Wu, Zhao et al.: "Molecular cloning and preliminary analysis of the human alpha-methylacyl-CoA racemase promoter." in: Molecular biology reports, Vol. 36, Issue 3, pp. 423-30, 2009 (PubMed).

Mubiru, Shen-Ong, Valente et al.: "Alternative spliced variants of the alpha-methylacyl-CoA racemase gene and their expression in prostate cancer." in: Gene, Vol. 327, Issue 1, pp. 89-98, 2004 (PubMed).