alpha-Methylacyl-CoA Racemase (AMACR) (C-Term), (AA 330-359) antibody

Details for Product No. ABIN950388
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Antigen
Synonyms AMACR, DKFZp469O1232, amacr, NCU04099.1, MGC89832, AMACRD, CBAS4, RACE, RM, Macr1, Da1-8, Marc1
Epitope
C-Term, AA 330-359
(12), (7), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(88), (28), (25)
Host
Rabbit
(69), (19)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(57), (31), (30), (29), (12), (10), (10), (8), (7), (2), (2)
Pubmed 5 references available
Quantity 0.4 mL
Shipping to United States (Change)
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Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN950388
357.50 $
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Immunogen KLH conjugated synthetic peptide between 330-359 amino acids from the C-terminal region of human AMACR
Specificity This antibody reacts to AMACR.
Purification Affinity chromatography on Protein A
Alternative Name AMACR / RACE
Background This gene encodes a racemase. The encoded enzyme interconverts pristanoyl-CoA and C27-bile acylCoAs between their (R)- and (S)-stereoisomers. The conversion to the (S)-stereoisomers is necessary for degradation of these substrates by peroxisomal beta- oxidation. Encoded proteins from this locus localize to both mitochondria and peroxisomes. Mutations in this gene may be associated with adult-onset sensorimotor neuropathy, pigmentary retinopathy, and adrenomyeloneuropathy due to defects in bile acid synthesis. Alternatively spliced transcript variants have been described.
Alternate names: 2-methylacyl-CoA racemase, Alpha-methylacyl-CoA racemase, P504S
Gene ID 23600
NCBI Accession NP_055139
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09% (w/v) sodium azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Mubiru, Shen-Ong, Valente et al.: "Alternative spliced variants of the alpha-methylacyl-CoA racemase gene and their expression in prostate cancer." in: Gene, Vol. 327, Issue 1, pp. 89-98, 2004 (PubMed).

Chen, Wu, Zhao et al.: "Molecular cloning and preliminary analysis of the human alpha-methylacyl-CoA racemase promoter." in: Molecular biology reports, Vol. 36, Issue 3, pp. 423-30, 2009 (PubMed).

Lakis, Papamitsou, Panagiotopoulou et al.: "AMACR is associated with advanced pathologic risk factors in sporadic colorectal adenomas." in: World journal of gastroenterology : WJG, Vol. 16, Issue 20, pp. 2476-83, 2010 (PubMed).

Sonwalkar, Rotimi, Scott et al.: "A study of indefinite for dysplasia in Barrett's oesophagus: reproducibility of diagnosis, clinical outcomes and predicting progression with AMACR (alpha-methylacyl-CoA-racemase)." in: Histopathology, Vol. 56, Issue 7, pp. 900-7, 2010 (PubMed).

Murray, Calaf, Badinez et al.: "P504S expressing circulating prostate cells as a marker for prostate cancer." in: Oncology reports, Vol. 24, Issue 3, pp. 687-92, 2010 (PubMed).

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