alpha-Methylacyl-CoA Racemase (AMACR) (C-Term), (AA 330-359) antibody

Details for Product No. ABIN950388
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Synonyms AMACR, DKFZp469O1232, amacr, NCU04099.1, MGC89832, AMACRD, CBAS4, RACE, RM, Macr1, Da1-8, Marc1
C-Term, AA 330-359
(22), (14), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
(123), (28), (25)
(98), (25)
(6), (5), (5), (4), (4), (4), (1), (1), (1), (1), (1), (1), (1), (1)
Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(92), (65), (36), (27), (19), (14), (13), (10), (9), (3), (3), (2), (2), (1), (1)
Pubmed 5 references available
Quantity 0.4 mL
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Request Want additional data for this product?

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Catalog No. ABIN950388
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Immunogen KLH conjugated synthetic peptide between 330-359 amino acids from the C-terminal region of human AMACR
Isotype Ig
Specificity This antibody reacts to AMACR.
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Affinity chromatography on Protein A
Alternative Name AMACR / RACE
Background This gene encodes a racemase. The encoded enzyme interconverts pristanoyl-CoA and C27-bile acylCoAs between their (R)- and (S)-stereoisomers. The conversion to the (S)-stereoisomers is necessary for degradation of these substrates by peroxisomal beta-oxidation. Encoded proteins from this locus localize to both mitochondria and peroxisomes. Mutations in this gene may be associated with adult-onset sensorimotor neuropathy, pigmentary retinopathy, and adrenomyeloneuropathy due to defects in bile acid synthesis. Alternatively spliced transcript variants have been described.Synonyms: 2-methylacyl-CoA racemase, Alpha-methylacyl-CoA racemase, P504S
Gene ID 23600
NCBI Accession NP_055139
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Murray, Calaf, Badinez et al.: "P504S expressing circulating prostate cells as a marker for prostate cancer." in: Oncology reports, Vol. 24, Issue 3, pp. 687-92, 2010 (PubMed).

Sonwalkar, Rotimi, Scott et al.: "A study of indefinite for dysplasia in Barrett's oesophagus: reproducibility of diagnosis, clinical outcomes and predicting progression with AMACR (alpha-methylacyl-CoA-racemase)." in: Histopathology, Vol. 56, Issue 7, pp. 900-7, 2010 (PubMed).

Lakis, Papamitsou, Panagiotopoulou et al.: "AMACR is associated with advanced pathologic risk factors in sporadic colorectal adenomas." in: World journal of gastroenterology : WJG, Vol. 16, Issue 20, pp. 2476-83, 2010 (PubMed).

Chen, Wu, Zhao et al.: "Molecular cloning and preliminary analysis of the human alpha-methylacyl-CoA racemase promoter." in: Molecular biology reports, Vol. 36, Issue 3, pp. 423-30, 2009 (PubMed).

Mubiru, Shen-Ong, Valente et al.: "Alternative spliced variants of the alpha-methylacyl-CoA racemase gene and their expression in prostate cancer." in: Gene, Vol. 327, Issue 1, pp. 89-98, 2004 (PubMed).

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