Regulatory Factor X-Associated Ankyrin Containing Protein (RFXANK) (AA 93-123), (Middle Region) antibody

Details for Product No. ABIN950419
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Synonyms ANKRA1, BLS, F14150_1, RFX-B, Tvl1
AA 93-123, Middle Region
(14), (13), (5), (4), (4), (2), (2), (1), (1)
(63), (2)
(37), (28)
(3), (2), (2), (2), (2), (2), (2)
Enzyme Immunoassay (EIA), Western Blotting (WB)
(59), (22), (20), (11), (11), (10), (6), (3), (3), (1), (1)
Pubmed 3 references available
Quantity 0.4 mL
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Catalog No. ABIN950419
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Immunogen KLH conjugated synthetic peptide between 93-123 amino acids from the Central region of human RFXANK. Genename: RFXANK
Isotype Ig
Specificity This antibody recognizes Human ANKRA1 / RFXANK (Center).
Purification Affinity Chromatography on Protein A
Alternative Name ANKRA1 / RFXANK
Background Major histocompatibility (MHC) class II molecules are transmembrane proteins that have a central role in development and control of the immune system. The protein encoded by this gene, along with regulatory factor X-associated protein and regulatory factor-5, forms a complex that binds to the X box motif of certain MHC class II gene promoters and activates their transcription. Once bound to the promoter, this complex associates with the non-DNA-binding factor MHC class II transactivator, which controls the cell type specificity and inducibility of MHC class II gene expression. This protein contains ankyrin repeats involved in protein-protein interactions. Mutations in this gene have been linked to bare lymphocyte syndrome type II, complementation group B. Two transcript variants encoding different isoforms have been described for this gene, with only one isoform showing activation activity.Synonyms: Ankyrin repeat family A protein 1, DNA-binding protein RFXANK, RFXB, Regulatory factor X subunit B, Regulatory factor X-associated ankyrin-containing protein
Molecular Weight 28102 Da
Gene ID 8625
NCBI Accession NP_003712
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS, 0.09 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Garvie, Boss: "Assembly of the RFX complex on the MHCII promoter: role of RFXAP and RFXB in relieving autoinhibition of RFX5." in: Biochimica et biophysica acta, Vol. 1779, Issue 12, pp. 797-804, 2008 (PubMed).

Wang, Grégoire, Zika et al.: "Identification of the ankyrin repeat proteins ANKRA and RFXANK as novel partners of class IIa histone deacetylases." in: The Journal of biological chemistry, Vol. 280, Issue 32, pp. 29117-27, 2005 (PubMed).

Grimwood, Gordon, Olsen et al.: "The DNA sequence and biology of human chromosome 19. ..." in: Nature, Vol. 428, Issue 6982, pp. 529-35, 2004 (PubMed).

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