RFXANK antibody (Middle Region)

Catalog No. ABIN950419

Product Details anti-RFXANK Antibody

Target: RFXANK (Regulatory Factor X-Associated Ankyrin Containing Protein (RFXANK))

Binding Specificity: AA 93-123, Middle Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RFXANK antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: This antibody recognizes Human ANKRA1 / RFXANK (Center).

Purification: Affinity Chromatography on Protein A

Immunogen: KLH conjugated synthetic peptide between 93-123 amino acids from the Central region of human RFXANK. Genename: RFXANK

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS, 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for RFXANK

Target: RFXANK (Regulatory Factor X-Associated Ankyrin Containing Protein (RFXANK))

Alternative Name: ANKRA1 / RFXANK (RFXANK Products)

Synonyms: ANKRA1 antibody, BLS antibody, F14150_1 antibody, RFX-B antibody, Tvl1 antibody, regulatory factor X associated ankyrin containing protein antibody, regulatory factor X-associated ankyrin-containing protein antibody, RFXANK antibody, Rfxank antibody

Background: Major histocompatibility (MHC) class II molecules are transmembrane proteins that have a central role in development and control of the immune system. The protein encoded by this gene, along with regulatory factor X-associated protein and regulatory factor-5, forms a complex that binds to the X box motif of certain MHC class II gene promoters and activates their transcription. Once bound to the promoter, this complex associates with the non-DNA-binding factor MHC class II transactivator, which controls the cell type specificity and inducibility of MHC class II gene expression. This protein contains ankyrin repeats involved in protein-protein interactions. Mutations in this gene have been linked to bare lymphocyte syndrome type II, complementation group B. Two transcript variants encoding different isoforms have been described for this gene, with only one isoform showing activation activity.Synonyms: Ankyrin repeat family A protein 1, DNA-binding protein RFXANK, RFXB, Regulatory factor X subunit B, Regulatory factor X-associated ankyrin-containing protein

Molecular Weight: 28102 Da

Gene ID: 8625

NCBI Accession: NP_003712