C4b-Binding Protein beta (AA 124-153), (Middle Region) antibody

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AA 124-153, Middle Region
Enzyme Immunoassay (EIA), Western Blotting (WB)
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Immunogen KLH conjugated synthetic peptide between 124-153 amino acids from the Central region of human C4BPB
Isotype Ig
Specificity This antibody reacts to C4b-binding protein beta.
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Affinity chromatography on Protein A
Background This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. A single, unique beta-chain encoded by this gene assembles with seven identical alpha-chains into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. C4b-binding protein has a regulatory role in the coagulation system also, mediated through the beta-chain binding of protein S, a vitamin K-dependent protein that serves as a cofactor of activated protein C. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Alternative splicing gives rise to multiple transcript variants.Synonyms: C4BPB
Gene ID 725
NCBI Accession NP_001017365
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09 % (W/V) sodium azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Western Blotting (WB) image for anti-C4b-Binding Protein beta (AA 124-153), (Middle Region) antibody (ABIN950920) C4BPB Antibody (Center) western blot analysis in A549 cell line lysates (35µg/lane).T...
Western Blotting (WB) image for anti-C4b-Binding Protein beta (AA 124-153), (Middle Region) antibody (ABIN950920) Western blot analysis of C4BPB (arrow) using rabbit polyclonal C4BPB Antibody (Center...
Background publications Buil, Trégouët, Souto, Saut, Germain, Rotival, Tiret, Cambien, Lathrop, Zeller, Alessi, Rodriguez de Cordoba, Münzel, Wild, Fontcuberta, Gagnon, Emmerich, Almasy, Blankenberg, Soria, Morange et al.: "C4BPB/C4BPA is a new susceptibility locus for venous thrombosis with unknown protein S-independent mechanism: results from genome-wide association and gene expression analyses followed by ..." in: Blood, Vol. 115, Issue 23, pp. 4644-50, 2010 (PubMed).

Han, Lan, Park, Lee, Park, Ahn, Shin, Kang, Koo, Seo, Choi, Ahn, Chanock, Kim, Rothman, Kang: "Polymorphisms in innate immunity genes and risk of childhood leukemia." in: Human immunology, Vol. 71, Issue 7, pp. 727-30, 2010 (PubMed).

Rajaraman, Brenner, Neta, Pfeiffer, Wang, Yeager, Thomas, Fine, Linet, Rothman, Chanock, Inskip: "Risk of meningioma and common variation in genes related to innate immunity." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 19, Issue 5, pp. 1356-61, 2010 (PubMed).

Davila, Froeling, Tan, Bonnard, Boland, Snippe, Hibberd, Seielstad: "New genetic associations detected in a host response study to hepatitis B vaccine." in: Genes and immunity, Vol. 11, Issue 3, pp. 232-8, 2010 (PubMed).

Hanna, Kruskal, Ezekowitz, Bloom, Collier: "Role of macrophage oxidative burst in the action of anthrax lethal toxin." in: Molecular medicine (Cambridge, Mass.), Vol. 1, Issue 1, pp. 7-18, 1996 (PubMed).