Chromosome 6 Open Reading Frame 150 (C6orf150) (AA 273-303), (Middle Region) antibody

Details for Product No. ABIN950947
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Antigen
Synonyms C6orf150, cGAS, h-cGAS
Epitope
AA 273-303, Middle Region
(7), (7), (2), (2), (1)
Reactivity
Human
(26), (12), (12), (12), (12), (1)
Host
Rabbit
(25), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
(17), (10), (9), (7), (3), (1)
Pubmed 2 references available
Quantity 0.4 mL
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Catalog No. ABIN950947
357.50 $
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Immunogen KLH conjugated synthetic peptide between 273-303 amino acids from the Central region of human CF150
Isotype Ig
Specificity This antibody recognizes Human C6orf150 (CF150). Other species not tested.
Purification Affinity chromatography on Protein A
Alternative Name C6orf150
Background Function: Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP. Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p]. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of double- stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production. Cellular Location: Cytoplasm, cytosol. Tissue Location: Expressed in the monocytic cell line THP1.Synonyms: Uncharacterized protein C6orf150
Molecular Weight 58814 Da
Gene ID 115004
NCBI Accession NP_612450
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS, 0.09 % (W/V) Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Mungall, Palmer, Sims et al.: "The DNA sequence and analysis of human chromosome 6. ..." in: Nature, Vol. 425, Issue 6960, pp. 805-11, 2003 (PubMed).

Rush, Moritz, Lee et al.: "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells." in: Nature biotechnology, Vol. 23, Issue 1, pp. 94-101, 2005 (PubMed).

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