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Chromosome 6 Open Reading Frame 150 (C6orf150) (AA 273-303), (Middle Region) antibody

Details for Product No. ABIN950947, Supplier: Log in to see
Antigen
  • C6orf150
  • cGAS
  • h-cGAS
Epitope
AA 273-303, Middle Region
8
6
2
2
2
1
1
1
Reactivity
Human
31
15
15
1
Host
Rabbit
31
Clonality
Polyclonal
Conjugate
Un-conjugated
5
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
20
13
11
7
3
1
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Immunogen KLH conjugated synthetic peptide between 273-303 amino acids from the Central region of human CF150
Isotype Ig
Specificity This antibody recognizes Human C6orf150 (CF150). Other species not tested.
Purification Affinity chromatography on Protein A
Alternative Name C6orf150 (C6orf150 Antibody Abstract)
Background Function: Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP. Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p]. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of double- stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production. Cellular Location: Cytoplasm, cytosol. Tissue Location: Expressed in the monocytic cell line THP1.Synonyms: Uncharacterized protein C6orf150
Molecular Weight 58814 Da
Gene ID 115004
NCBI Accession NP_612450
Pathways
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS, 0.09 % (W/V) Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Flow Cytometry (FACS) image for anti-Chromosome 6 Open Reading Frame 150 (C6orf150) (AA 273-303), (Middle Region) antibody (ABIN950947) Flow Cytometric analysis of MDA-MB231 cells using CF150 Antibody (Center) Cat.-No AP5...
Western Blotting (WB) image for anti-Chromosome 6 Open Reading Frame 150 (C6orf150) (AA 273-303), (Middle Region) antibody (ABIN950947) Western blot analysis in MDA-MB231 cell line lysates using CF150 Antibody (Center) Ca...
Background publications Rush, Moritz, Lee et al.: "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells." in: Nature biotechnology, Vol. 23, Issue 1, pp. 94-101, 2005 (PubMed).

Mungall, Palmer, Sims et al.: "The DNA sequence and analysis of human chromosome 6. ..." in: Nature, Vol. 425, Issue 6960, pp. 805-11, 2003 (PubMed).