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C6orf150 antibody

C6orf150 Reactivity: Human WB, ELISA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7244735
  • Target See all C6orf150 Antibodies
    C6orf150 (Chromosome 6 Open Reading Frame 150 (C6orf150))
    Reactivity
    • 29
    • 7
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 32
    • 1
    Rabbit
    Clonality
    • 32
    • 1
    Polyclonal
    Conjugate
    • 16
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This C6orf150 antibody is un-conjugated
    Application
    • 27
    • 16
    • 7
    • 7
    • 6
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA
    Characteristics
    Polyclonal Antibody
    Purification
    Antigen affinity purification
    Immunogen
    Synthetic peptide of human MB21D1
    Isotype
    IgG
    Top Product
    Discover our top product C6orf150 Primary Antibody
  • Application Notes
    WB 1:500-1:2000, ELISA 1:5000-1:10000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.78 mg/mL
    Buffer
    PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    C6orf150 (Chromosome 6 Open Reading Frame 150 (C6orf150))
    Alternative Name
    CGAS (C6orf150 Products)
    Synonyms
    C6orf150 antibody, cGAS antibody, h-cGAS antibody, Mab-21 domain containing 1 antibody, cyclic GMP-AMP synthase antibody, MB21D1 antibody, CGAS antibody
    Background
    Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP. Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p]. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production. cGAMP can be transferred between cells by virtue of packaging within viral particles contributing to IFN-induction in newly infected cells in a cGAS-independent but TMEM173/STING-dependent manner (PubMed:26229115).
    Molecular Weight

    Observed_MW: Refer to figures

    Calculated_MW: 59 kDa

    UniProt
    Q8N884
    Pathways
    Activation of Innate immune Response
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