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CPN1 antibody (Carboxypeptidase N Subunit 1) (AA 209-240)

Details for Product anti-CPN1 Antibody No. ABIN951036, Supplier: Login to see New
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Synonyms cb1037, fa99g08, wu:fa99g08, zgc:77485, cpn, scpn, CPN, SCPN, 0610011F20Rik, Cpn, AA389061, CPN1, Cyp11b, Cyp11b-1, FHI
AA 209-240, Middle Region
(7), (3), (3), (3), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1)
(43), (14), (9), (2), (2), (2), (1), (1), (1)
This CPN1 antibody is un-conjugated
(3), (3)
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(41), (21), (14), (4), (3), (2), (1), (1)
Pubmed 5 references available
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Quantity 0.4 mL
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Immunogen KLH conjugated synthetic peptide between 209-240 amino acids from the Central region of Human CPN1. Genename: CPN1
Isotype Ig
Specificity This antibody recognizes Human CPN1 (Center).
Purification Affinity Chromatography on Protein A
Alternative Name Carboxypeptidase N Catalytic Chain (CPN1 Antibody Abstract)
Background Carboxypeptidase N is a plasma metallo-protease that cleaves basic amino acids from the C terminal of peptides and proteins. The enzyme is important in the regulation of peptides like kinins and anaphylatoxins, and has also been known as kininase-1 and anaphylatoxin inactivator. This enzyme is a tetramer comprised of two identical regulatory subunits and two identical catalytic subunits, this gene encodes the catalytic subunit. Mutations in this gene can be associated with angioedema or chronic urticaria resulting from carboxypeptidase N deficiency. [provided by RefSeq].Synonyms: ACBP, Anaphylatoxin inactivator, Arginine carboxypeptidase, CPN, CPN1, Carboxypeptidase N polypeptide 1, Carboxypeptidase N small subunit, Kininase-1, Lysine carboxypeptidase, Plasma carboxypeptidase B, SCPN, Serum carboxypeptidase N
Molecular Weight 52286 Da
Gene ID 1369
NCBI Accession NP_001299
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS, 0.09 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-CPN1 antibody (Carboxypeptidase N Subunit 1) (AA 209-240) (ABIN951036) Formalin fixed and paraffin embedded human liver tissue stained with CPN1 Antibody (C...
Western Blotting (WB) image for anti-CPN1 antibody (Carboxypeptidase N Subunit 1) (AA 209-240) (ABIN951036) Western blot analysis of CPN1 (arrow) using CPN1 Antibody (Center) Cat.-No AP51053PU-...
Background publications Speliotes, Butler, Palmer et al.: "PNPLA3 variants specifically confer increased risk for histologic nonalcoholic fatty liver disease but not metabolic disease." in: Hepatology (Baltimore, Md.), Vol. 52, Issue 3, pp. 904-12, 2010 (PubMed).

Ichikawa, Koller, Padgett et al.: "Replication of previous genome-wide association studies of bone mineral density in premenopausal American women." in: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Vol. 25, Issue 8, pp. 1821-9, 2010 (PubMed).

Du, Zabel, Myles et al.: "Regulation of chemerin bioactivity by plasma carboxypeptidase N, carboxypeptidase B (activated thrombin-activable fibrinolysis inhibitor), and platelets." in: The Journal of biological chemistry, Vol. 284, Issue 2, pp. 751-8, 2009 (PubMed).

Yuan, Waterworth, Perry et al.: "Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes." in: American journal of human genetics, Vol. 83, Issue 4, pp. 520-8, 2008 (PubMed).

Skidgel, Erdös: "Structure and function of human plasma carboxypeptidase N, the anaphylatoxin inactivator." in: International immunopharmacology, Vol. 7, Issue 14, pp. 1888-99, 2007 (PubMed).

Catalog No. ABIN951036
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