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Signaling Lymphocytic Activation Molecule Family Member 1 (SLAMF1) antibody

Details for Product No. ABIN951192, Supplier: Login to see
Antigen
  • CD150
  • SLAM
  • SLAMF1
  • 4933415F16
  • AA177906
  • CDw150
  • ESTM51
  • IPO-3
  • Slam
  • RGD1560634
Reactivity
Human
169
122
36
3
Host
Mouse
111
86
62
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
28
26
20
9
6
6
5
4
3
2
2
2
2
2
2
2
2
2
2
1
1
1
Application
Flow Cytometry (FACS), Immunofluorescence (IF), Immunoprecipitation (IP)
134
72
55
29
22
18
13
13
10
9
8
8
4
4
3
2
2
1
Supplier
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Immunogen Human CD150-transfected 300.19 cells
Clone SLAM-4
Isotype IgG1
Specificity This Monoclonal SLAM.4 antibody recognizes CD150, a cell surface molecule expressed on lymphocytes and involved in their activation.
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Protein A-affinity chromatography
Alternative Name CD150 / SLAMF1 (SLAMF1 Antibody Abstract)
Background CD150, also known as SLAM (signaling lymphocyte activation molecule) is a 70-95 kDa single chain transmembrane phosphoglycoprotein of the CD2 family. Its extracellular part contains eight potential N-glycosylation sites, and the intracellular tail contains three unique tyrosine-based motifs. These binding sites can be recognized by SH2-binding phosphatases and the adaptor proteins, such as SAP/SH2D1A or EAT-2. The SLAM family receptors are involved in leucocyte activation and contribute to the effective germinal center formation, generation of high-affinity antibody-secreting plasma cells, and memory T and B cells, thereby facilitating long-term immune response. CD150 expression is upregulated after cell activation.Synonyms: CDw150, Ipo-3, Signaling lymphocytic activation molecule, Slam
Gene ID 6504
NCBI Accession NP_003028
UniProt Q13291
Pathways
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 1.0 mg/mL (> 95% pure by SDS-PAGE)
Buffer Azide free phosphate buffered saline (PBS), pH ~7.4, 0.2 μm filter sterilized
Preservative Azide free
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.
Background publications Romero, Zapater, Calvo et al.: "CD229 (Ly9) lymphocyte cell surface receptor interacts homophilically through its N-terminal domain and relocalizes to the immunological synapse." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 174, Issue 11, pp. 7033-42, 2005 (PubMed).

Romero, Benítez, March et al.: "Differential expression of SAP and EAT-2-binding leukocyte cell-surface molecules CD84, CD150 (SLAM), CD229 (Ly9) and CD244 (2B4)." in: Tissue antigens, Vol. 64, Issue 2, pp. 132-44, 2004 (PubMed).

García, Quiroga, Ochoa et al.: "Signaling lymphocytic activation molecule expression and regulation in human intracellular infection correlate with Th1 cytokine patterns." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 167, Issue 10, pp. 5719-24, 2001 (PubMed).