Signaling Lymphocytic Activation Molecule Family Member 1 (SLAMF1) antibody

Details for Product No. ABIN951192
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Antigen
Synonyms CD150, SLAM, SLAMF1, 4933415F16, AA177906, CDw150, ESTM51, IPO-3, Slam, RGD1560634
Reactivity
Human
(131), (81), (32), (12), (12), (12), (6)
Host
Mouse
(81), (52), (49)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(21), (20), (16), (6), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application
Immunocytochemistry (ICC), Immunofluorescence (IF), Immunoprecipitation (IP), Flow Cytometry (FACS)
(93), (55), (39), (20), (18), (12), (10), (9), (7), (5), (3), (2), (1), (1)
Pubmed 3 references available
Quantity 0.1 mg
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
Request Want additional data for this product?

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Catalog No. ABIN951192
308.00 $
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Immunogen Human CD150-transfected 300.19 cells
Clone SLAM-4
Isotype IgG1
Specificity This antibody recognizes CD150, a cell surface molecule expressed on lymphocytes and involved in their activation.
Purification Protein A-affinity chromatography
Alternative Name CD150 / SLAMF1
Background CD150, also known as SLAM (signaling lymphocyte activation molecule) is a 70-95 kDa single chain transmembrane phosphoglycoprotein of the CD2 family. Its extracellular part contains eight potential N-glycosylation sites, and the intracellular tail contains three unique tyrosine-based motifs. These binding sites can be recognized by SH2-binding phosphatases and the adaptor proteins, such as SAP/SH2D1A or EAT-2. The SLAM family receptors are involved in leucocyte activation and contribute to the effective germinal center formation, generation of high-affinity antibody-secreting plasma cells, and memory T and B cells, thereby facilitating long-term immune response. CD150 expression is upregulated after cell activation.
Alternate names: CDw150, Ipo-3, Signaling lymphocytic activation molecule, Slam
Gene ID 6504
NCBI Accession NP_003028
UniProt Q13291
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL (> 95% pure by SDS-PAGE)
Buffer Azide free phosphate buffered saline (PBS), approx. pH 7.4, 0.2 μm filter sterilized
Preservative Azide free
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.
Expiry Date 12 months
Background publications García, Quiroga, Ochoa et al.: "Signaling lymphocytic activation molecule expression and regulation in human intracellular infection correlate with Th1 cytokine patterns." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 167, Issue 10, pp. 5719-24, 2001 (PubMed).

Romero, Benítez, March et al.: "Differential expression of SAP and EAT-2-binding leukocyte cell-surface molecules CD84, CD150 (SLAM), CD229 (Ly9) and CD244 (2B4)." in: Tissue antigens, Vol. 64, Issue 2, pp. 132-44, 2004 (PubMed).

Romero, Zapater, Calvo et al.: "CD229 (Ly9) lymphocyte cell surface receptor interacts homophilically through its N-terminal domain and relocalizes to the immunological synapse." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 174, Issue 11, pp. 7033-42, 2005 (PubMed).

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