CES2 (AA 343-373), (Middle Region) antibody

Details for Product No. ABIN951482
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Antigen
Synonyms CE-2, CES2A1, PCE-2, iCE, Ces2, ces2A3, EG436059, Gm5744
Epitope
AA 343-373, Middle Region
(9), (9), (6), (4), (4), (4), (4), (3), (3), (2), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(57), (9), (4), (3)
Host
Rabbit
(47), (17), (2), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (2)
Application
Enzyme Immunoassay (EIA), Flow Cytometry (FACS), Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(58), (42), (24), (10), (8), (6), (4), (4), (2)
Pubmed 3 references available
Quantity 0.4 mL
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
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Catalog No. ABIN951482
357.50 $
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Immunogen KLH conjugated synthetic peptide between 343-373 amino acids from the Central region of human CES2
Isotype Ig
Specificity This antibody reacts to CES2.
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Affinity chromatography on Protein A
Alternative Name CES2 / ICE
Background CES2 is a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. The protein encoded by this gene is the major intestinal enzyme and functions in intestine drug clearance.Synonyms: CE-2, Carboxylesterase 2, hCE-2
Molecular Weight 61807 Da
Gene ID 8824
NCBI Accession NP_003860
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS, 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Howard, Hsu, Grzywacz et al.: "Evaluation of candidate genes for cholinesterase activity in farmworkers exposed to organophosphorus pesticides: association of single nucleotide polymorphisms in BCHE." in: Environmental health perspectives, Vol. 118, Issue 10, pp. 1395-9, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Hatfield, Tsurkan, Hyatt et al.: "Biochemical and molecular analysis of carboxylesterase-mediated hydrolysis of cocaine and heroin." in: British journal of pharmacology, Vol. 160, Issue 8, pp. 1916-28, 2010 (PubMed).

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