Collagen Type XVIII alpha 1 Chain (AA 1314-1343), (Middle Region), (Chain alpha 1) antibody

Details for Product No. ABIN951630
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AA 1314-1343, Middle Region, Chain alpha 1
(11), (2), (1), (1)
Human, Mouse (Murine)
(10), (6), (1)
(6), (5), (1)
ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(8), (7), (6), (2), (1), (1), (1)
Pubmed 2 references available
Catalog no. ABIN951630
Quantity 0.4 mL
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Immunogen KLH conjugated synthetic peptide between 1314-1343 amino acids from the Central region of Human COL18A1 Genename: COL18A1
Purification Protein A column, followed by peptide affinity purification
Background COL18A1 is the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. The proteolytically produced C- terminal fragment of type XVIII collagen is endostatin, a potent antiangiogenic protein. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities, so type XVIII collagen may play an important role in retinal structure and in neural tube closure.
Alternate names: COL18A1, Endostatin, KNO1
Gene ID 80781
NCBI Accession NP_085059
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS 0.09% (w/v) Sodium Azide
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Roberts, Kawut, Krowka et al.: "Genetic risk factors for hepatopulmonary syndrome in patients with advanced liver disease." in: Gastroenterology, Vol. 139, Issue 1, pp. 130-9.e24, 2010 (PubMed).

Hamano, Okude, Shirai et al.: "Lack of collagen XVIII/endostatin exacerbates immune-mediated glomerulonephritis." in: Journal of the American Society of Nephrology : JASN, Vol. 21, Issue 9, pp. 1445-55, 2010 (PubMed).

Hosts (6), (5), (1)
Reactivities (10), (6), (1)
Applications (8), (7), (6), (2), (1), (1), (1)
Epitopes (11), (2), (1), (1)
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