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Cleavage and Polyadenylation Specific Factor 4, 30kDa (CPSF4) (AA 102-132), (Middle Region) antibody

Details for Product No. ABIN951684
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Antigen
Synonyms cpsf30, nar, neb1, 30kDa, C79664, CPSF30, NAR, NEB1
Epitope
AA 102-132, Middle Region
(7), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(36), (16), (15), (13), (13), (13), (12)
Host
Rabbit
(31), (7)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB)
(26), (8), (8), (3), (3), (3), (2), (2), (1)
Pubmed 4 references available
Quantity 0.4 mL
Shipping to United States (Change)
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Catalog No. ABIN951684
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Immunogen KLH conjugated synthetic peptide between 102~132 amino acids from the Central region of Human CPSF4. Genename: CPSF4
Specificity This antibody recognizes Human CPSF4 (Center).
Purification Affinity Chromatography on Protein A
Alternative Name CPSF4
Background Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. The NS1 effector domain functionally interacts with the cellular 30 kDa subunit of cleavage and polyadenylation specific factor 4, an essential component of the 3' end processing machinery of cellular pre-mRNAs. In influenza virus-infected cells, the NS1 protein is physically associated with cleavage and polyadenylation specific factor 4, 30kD subunit. Binding of the NS1 protein to the 30 kDa protein in vitro prevents CPSF binding to the RNA substrate and inhibits 3' end cleavage and polyadenylation of host pre-mRNAs. Thus the NS1 protein selectively inhibits the nuclear export of cellular, and not viral, mRNAs.
Alternate names: CPSF30, Cleavage and polyadenylation specificity factor 30 kDa subunit, Cleavage and polyadenylation specificity factor subunit 4, NAR, NEB1, NS1 effector domain-binding protein 1, No arches homolog
Molecular Weight 30255 Da
Gene ID 10898
NCBI Accession NP_001075028
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS 0.09% Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications de Vries, Rüegsegger, Hübner et al.: "Human pre-mRNA cleavage factor II(m) contains homologs of yeast proteins and bridges two other cleavage factors." in: The EMBO journal, Vol. 19, Issue 21, pp. 5895-904, 2000 (PubMed).

Kaufmann, Martin, Friedlein et al.: "Human Fip1 is a subunit of CPSF that binds to U-rich RNA elements and stimulates poly(A) polymerase." in: The EMBO journal, Vol. 23, Issue 3, pp. 616-26, 2004 (PubMed).

Oh, Yang, Hahn et al.: "Transcriptome analysis of human gastric cancer." in: Mammalian genome : official journal of the International Mammalian Genome Society, Vol. 16, Issue 12, pp. 942-54, 2005 (PubMed).

Twu, Kuo, Marklund et al.: "The H5N1 influenza virus NS genes selected after 1998 enhance virus replication in mammalian cells." in: Journal of virology, Vol. 81, Issue 15, pp. 8112-21, 2007 (PubMed).

Validation Images
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