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Cytochrome P450, Family 27, Subfamily B, Polypeptide 1 (CYP27B1) (AA 479-508), (C-Term) antibody

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Synonyms cp2b, cyp1, cyp1alpha, cyp27b, p450c1, pddr, vdd1, vddr, vddri, vdr, CP2B, CYP1, CYP1alpha, CYP27B, P450c1, PDDR, VDD1, VDDR, VDDRI, VDR, Cyp40, Cp2b, Cyp1, Cyp27b, Pddr, Vdd1, Vddr, VddrI, Vdr
AA 479-508, C-Term
(7), (4), (4), (4), (2), (2), (1), (1)
(13), (6), (5)
Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(14), (11), (11), (7), (7), (6), (4)
Pubmed 2 references available
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Quantity 0.4 mL
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Immunogen KLH conjugated synthetic peptide between 479~508 amino acids from the C-terminal region of Human CYP27B1
Isotype Ig
Specificity Recognizes CYP27B1 (C-term).
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS
Alternative Name CYP27B1 (CYP27B1 Antibody Abstract)
Background CYP27B1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the inner mitochondrial membrane where it hydroxylates 25-hydroxyvitamin D3 at the 1alpha position. This reaction synthesizes 1alpha,25-dihydroxyvitamin D3, the active form of vitamin D3, which binds to the vitamin D receptor and regulates calcium metabolism. Thus this enzyme regulates the level of biologically active vitamin D and plays an important role in calcium homeostasis. Mutations in this gene can result in vitamin D-dependent rickets type I.Synonyms: 25-OHD-1 alpha-hydroxylase, 25-hydroxyvitamin D(3) 1-alpha-hydroxylase, 25-hydroxyvitamin D-1 alpha hydroxylase, CYP1ALPHA, CYP27B, Calcidiol 1-monooxygenase, Cytochrome P450 subfamily XXVIIB polypeptide 1, Cytochrome P450C1 alpha, Cytochrome P450VD1-alpha, Cytochrome p450 27B1, VD3 1A hydroxylase
Gene ID 1594
NCBI Accession NP_000776
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS, 0.09 % (W/V) Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Flow Cytometry (FACS) image for anti-Cytochrome P450, Family 27, Subfamily B, Polypeptide 1 (CYP27B1) (AA 479-508), (C-Term) antibody (ABIN951779) Flow cytometric analysis of 293 cells using CYP27B1 Antibody (C-term) Cat.-No
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Cytochrome P450, Family 27, Subfamily B, Polypeptide 1 (CYP27B1) (AA 479-508), (C-Term) antibody (ABIN951779) Immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney ti...
Western Blotting (WB) image for anti-Cytochrome P450, Family 27, Subfamily B, Polypeptide 1 (CYP27B1) (AA 479-508), (C-Term) antibody (ABIN951779) Western blot analysis of CYP27B1 Antibody (C-term)  in mouse kidney tissue lysate...
Background publications Simon, Munger, Xing Yang et al.: "Polymorphisms in vitamin D metabolism related genes and risk of multiple sclerosis." in: Multiple sclerosis (Houndmills, Basingstoke, England), Vol. 16, Issue 2, pp. 133-8, 2010 (PubMed).

Zhou, LeBoff, Glowacki: "Vitamin D metabolism and action in human bone marrow stromal cells." in: Endocrinology, Vol. 151, Issue 1, pp. 14-22, 2009 (PubMed).

Catalog No. ABIN951779
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