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FXYD Domain Containing Ion Transport Regulator 5 (FXYD5) (AA 70-100), (Middle Region) antibody

Details for Product No. ABIN952009
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Antigen
Synonyms DYSAD, IWU1, KCT1, OIT2, PRO6241, RIC, EF-8, Oit2, FXYD5
Epitope
AA 70-100, Middle Region
(8), (7), (4), (2), (2)
Reactivity
Human
(23)
Host
Rabbit
(19), (7)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), ELISA, Western Blotting (WB)
(24), (10), (8), (2)
Pubmed 5 references available
Quantity 0.4 mL
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
Catalog No. ABIN952009
357.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen KLH conjugated synthetic peptide between 70-100 amino acids from the Central region of Human Dysadherin / FXYD5
Specificity This antibody recognizes Human Dysadherin / FXYD5 (Center).
Purification Protein A column, followed by peptide affinity purification
Alternative Name Dysadherin / FXYD5
Background This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K- ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. This gene product, FXYD5, is a glycoprotein that functions in the up-regulation of chemokine production, and it is involved in the reduction of cell adhesion via its ability to down-regulate E-cadherin. It also promotes metastasis, and has been linked to a variety of cancers. Alternative splicing results in multiple transcript variants. [RefSeq curation by Kathleen J. Sweadner, Ph.D., sweadner@helix.mgh.harvard.edu.].
Alternate names: DYSAD, FXYD domain-containing ion transport regulator 5, IWU1
Gene ID 53827
NCBI Accession NP_001158077
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09% (w/v) Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Batistatou, Charalabopoulos, Nakanishi et al.: "Differential expression of dysadherin in papillary thyroid carcinoma and microcarcinoma: correlation with E-cadherin." in: Endocrine pathology, Vol. 19, Issue 3, pp. 197-202, 2008 (PubMed).

Liang, Zheng, Xiao et al.: "Dysadherin expression in gastrointestinal stromal tumors (GISTs)." in: Pathology, research and practice, Vol. 205, Issue 7, pp. 445-50, 2009 (PubMed).

Talmud, Drenos, Shah et al.: "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip." in: American journal of human genetics, Vol. 85, Issue 5, pp. 628-42, 2009 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Ono, Uramoto, Hanagiri: "Expression of dysadherin and cytokeratin as prognostic indicators of disease-free survival in patients with stage I NSCLC." in: Anticancer research, Vol. 30, Issue 9, pp. 3273-8, 2010 (PubMed).

Hosts (19), (7)
Reactivities (23)
Applications (24), (10), (8), (2)
Conjugates (1), (1), (1), (1), (1), (1)
Epitopes (8), (7), (4), (2), (2)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN952009
357.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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