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ER Degradation Enhancer, Mannosidase alpha-Like 3 (EDEM3) (AA 773-802), (C-Term) antibody

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Synonyms RGD1561496, C1orf22, 2310050N11Rik
C-Term, AA 773-802
(20), (15), (2)
(23), (2), (2)
(2), (2), (2), (2), (2), (2)
Enzyme Immunoassay (EIA), Western Blotting (WB)
(21), (15)
Pubmed 4 references available
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Quantity 0.4 mL
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Immunogen KLH conjugated synthetic peptide between 773-802 amino acids from the C-terminal region of human EDEM3
Isotype Ig
Specificity This antibody recognizes Human EDEM3 (C-term).
Purification Affinity Chromatography on Protein A
Alternative Name EDEM3 (EDEM3 Antibody Abstract)
Background Quality control in the endoplasmic reticulum (ER) ensures that only properly folded proteins are retained in the cell through recognition and degradation of misfolded or unassembled proteins. EDEM3 belongs to a group of proteins that accelerate degradation of misfolded glycoproteins in the ER (Hirao et al., 2006 [PubMed 16431915]).Synonyms: C1orf22, ER degradation-enhancing alpha-mannosidase-like 3
Molecular Weight 104664 Da
Gene ID 80267
NCBI Accession NP_079467
Research Area Signaling
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09 % (W/V) Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Western Blotting (WB) image for anti-ER Degradation Enhancer, Mannosidase alpha-Like 3 (EDEM3) (AA 773-802), (C-Term) antibody (ABIN952023) Western blot analysis of EDEM3 Antibody (C-term) in A2058 cell line lysates (35ug/lan...
Background publications Hirao, Natsuka, Tamura et al.: "EDEM3, a soluble EDEM homolog, enhances glycoprotein endoplasmic reticulum-associated degradation and mannose trimming." in: The Journal of biological chemistry, Vol. 281, Issue 14, pp. 9650-8, 2006 (PubMed).

Olivari, Galli, Alanen et al.: "A novel stress-induced EDEM variant regulating endoplasmic reticulum-associated glycoprotein degradation." in: The Journal of biological chemistry, Vol. 280, Issue 4, pp. 2424-8, 2005 (PubMed).

Mast, Diekman, Karaveg et al.: "Human EDEM2, a novel homolog of family 47 glycosidases, is involved in ER-associated degradation of glycoproteins." in: Glycobiology, Vol. 15, Issue 4, pp. 421-36, 2005 (PubMed).

Sood, Bonner, Makalowska et al.: "Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus." in: Genomics, Vol. 73, Issue 2, pp. 211-22, 2001 (PubMed).

Catalog No. ABIN952023
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