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Coagulation Factor II (thrombin) Receptor-Like 2 (F2RL2) (AA 20-50), (N-Term) antibody

Details for Product No. ABIN952152, Supplier: Login to see
Antigen
  • par3
  • PAR-3
  • PAR3
  • F730031A08
  • ASIP
  • Baz
  • PAR3alpha
  • PARD-3
  • PARD3A
  • SE2-5L16
  • SE2-5LT1
  • SE2-5T2
Epitope
AA 20-50, N-Term
17
15
6
5
2
1
Reactivity
Human
50
14
14
Host
Rabbit
50
Clonality
Polyclonal
Conjugate
Un-conjugated
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
23
21
18
11
11
6
3
Supplier
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Immunogen KLH conjugated synthetic peptide between 20-50 amino acids from the N-terminal region of human F2RL2
Isotype Ig
Specificity This antibody recognizes Human F2RL2 (N-term).
Purification Affinity Chromatography on Protein A
Alternative Name F2RL2 (F2RL2 Antibody Abstract)
Background Coagulation factor II (thrombin) receptor-like 2 (F2RL2) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL2 is also a member of the protease-activated receptor family and activated by thrombin. F2RL2 is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. F2RL2 is a cofactor for F2RL3 activation by thrombin. It mediates thrombin-triggered phosphoinositide hydrolysis and is expressed in a variety of tissues.Synonyms: Coagulation factor II receptor-like 2, PAR-3, PAR3, Proteinase-activated receptor 3, Thrombin receptor-like 2
Molecular Weight 42508 Da
Gene ID 2151
NCBI Accession NP_004092
Pathways
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09 % (W/V) Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Coagulation Factor II (thrombin) Receptor-Like 2 (F2RL2) (AA 20-50), (N-Term) antibody (ABIN952152) Formalin fixed and paraffin embedded human heart tissue reacted with F2RL2 Antibody (...
Western Blotting (WB) image for anti-Coagulation Factor II (thrombin) Receptor-Like 2 (F2RL2) (AA 20-50), (N-Term) antibody (ABIN952152) Western blot analysis of F2RL2 Antibody (N-term) in NCI-H292 cell line lysates (35ug/...
Background publications Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Wysoczynski, Liu, Kucia et al.: "Thrombin regulates the metastatic potential of human rhabdomyosarcoma cells: distinct role of PAR1 and PAR3 signaling." in: Molecular cancer research : MCR, Vol. 8, Issue 5, pp. 677-90, 2010 (PubMed).

Popović, Paskas, Zivković et al.: "Human cytomegalovirus increases HUVEC sensitivity to thrombin and modulates expression of thrombin receptors." in: Journal of thrombosis and thrombolysis, Vol. 30, Issue 2, pp. 164-71, 2010 (PubMed).

Van Laer, Huyghe, Hannula et al.: "A genome-wide association study for age-related hearing impairment in the Saami." in: European journal of human genetics : EJHG, Vol. 18, Issue 6, pp. 685-93, 2010 (PubMed).