Homeodomain Interacting Protein Kinase 1 (HIPK1) (C-Term), (AA 892-922) antibody

Details for Product No. ABIN952740
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Antigen
Synonyms HIPK1, myak, nbak2, hipk1, Myak, Nbak2, 1110062K04Rik
Epitope
C-Term, AA 892-922
(10), (8), (7), (2), (2), (1), (1), (1)
Reactivity
Human
(26), (1), (1), (1), (1)
Host
Rabbit
(14), (12)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(22), (15), (8), (6), (5), (1), (1)
Pubmed 5 references available
Quantity 0.4 mL
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Catalog No. ABIN952740
357.50 $
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Immunogen KLH conjugated synthetic peptide between 892-922 amino acids from the C-terminal region of human HIPK1
Isotype Ig
Specificity This antibody recognizes Human HIPK1 (C-term).
Purification Protein A column, followed by peptide affinity purification
Alternative Name HIPK1
Background The protein encoded by this gene belongs to the Ser/Thr family of protein kinases and HIPK subfamily. It phosphorylates homeodomain transcription factors and may also function as a co-repressor for homeodomain transcription factors. Alternative splicing results in four transcript variants encoding four distinct isoforms.Synonyms: Homeodomain-interacting protein kinase 1, KIAA0630
Molecular Weight 130843 Da
Gene ID 204851
NCBI Accession NP_689909
Research Area Chromatin and Nuclear Signaling, Transcription Factors
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09 % (W/V) Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Song, Lee: "Role of the ASK1-SEK1-JNK1-HIPK1 signal in Daxx trafficking and ASK1 oligomerization." in: The Journal of biological chemistry, Vol. 278, Issue 47, pp. 47245-52, 2003 (PubMed).

Colland, Jacq, Trouplin et al.: "Functional proteomics mapping of a human signaling pathway." in: Genome research, Vol. 14, Issue 7, pp. 1324-32, 2004 (PubMed).

Rush, Moritz, Lee et al.: "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells." in: Nature biotechnology, Vol. 23, Issue 1, pp. 94-101, 2005 (PubMed).

Li, Zhang, Luo et al.: "Tumor necrosis factor alpha-induced desumoylation and cytoplasmic translocation of homeodomain-interacting protein kinase 1 are critical for apoptosis signal-regulating kinase 1-JNK/p38 activation." in: The Journal of biological chemistry, Vol. 280, Issue 15, pp. 15061-70, 2005 (PubMed).

Matre, Nordgård, Alm-Kristiansen et al.: "HIPK1 interacts with c-Myb and modulates its activity through phosphorylation." in: Biochemical and biophysical research communications, Vol. 388, Issue 1, pp. 150-4, 2009 (PubMed).

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