Homeobox B8 (HOXB8) (C-Term), (AA 214-243) antibody

Details for Product No. ABIN952779
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Synonyms Hox2r1a, HOX2, HOX2D, Hox-2.4
C-Term, AA 214-243
(32), (16), (14), (4), (2), (2), (1), (1), (1), (1), (1)
(52), (21), (13), (2), (1), (1)
(52), (7)
(5), (5), (5), (4), (4), (4), (1), (1), (1), (1), (1), (1), (1), (1)
Enzyme Immunoassay (EIA), Western Blotting (WB)
(48), (28), (10), (6), (3), (1)
Pubmed 5 references available
Quantity 0.4 mL
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Catalog No. ABIN952779
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Immunogen KLH conjugated synthetic peptide between 214-243 amino acids from the C-terminal region of human HOXB8
Isotype Ig
Specificity This antibody recognizes Human HOXB8 / HOX2D (C-term).
Purification Protein A column, followed by peptide affinity purification
Alternative Name HOXB8 / HOX2D
Background This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with colorectal cancer. Mice that have had the murine ortholog of this gene knocked out exhibit an excessive pathologic grooming behavior. This behavior is similar to the behavior of humans suffering from the obsessive-compulsive spectrum disorder trichotillomania.Synonyms: Homeobox protein Hox-B8, Hox-2.4, Hox-2D
Molecular Weight 27574 Da
Gene ID 3218
NCBI Accession NP_076921
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09 % (W/V) Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Kosaki, Kosaki, Suzuki et al.: "Complete mutation analysis panel of the 39 human HOX genes." in: Teratology, Vol. 65, Issue 2, pp. 50-62, 2002 (PubMed).

Greer, Capecchi: "Hoxb8 is required for normal grooming behavior in mice." in: Neuron, Vol. 33, Issue 1, pp. 23-34, 2002 (PubMed).

Knoepfler, Sykes, Pasillas et al.: "HoxB8 requires its Pbx-interaction motif to block differentiation of primary myeloid progenitors and of most cell line models of myeloid differentiation." in: Oncogene, Vol. 20, Issue 39, pp. 5440-8, 2001 (PubMed).

Fujino, Yamazaki, Largaespada et al.: "Inhibition of myeloid differentiation by Hoxa9, Hoxb8, and Meis homeobox genes." in: Experimental hematology, Vol. 29, Issue 7, pp. 856-63, 2001 (PubMed).

Vider, Zimber, Hirsch et al.: "Human colorectal carcinogenesis is associated with deregulation of homeobox gene expression." in: Biochemical and biophysical research communications, Vol. 232, Issue 3, pp. 742-8, 1997 (PubMed).

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