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Homeobox B8 (HOXB8) (C-Term), (AA 214-243) antibody

Details for Product No. ABIN952779
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Antigen
Synonyms HOX2, HOX2D, Hox-2.4, Hox2r1a
Epitope
C-Term, AA 214-243
(16), (9), (7), (3), (2), (2), (1), (1), (1), (1)
Reactivity
Human
(35), (21), (14), (13), (12), (1), (1)
Host
Rabbit
(36), (6)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB)
(31), (22), (10), (3), (1)
Pubmed 5 references available
Quantity 0.4 mL
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
Catalog No. ABIN952779
357.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen KLH conjugated synthetic peptide between 214-243 amino acids from the C-terminal region of human HOXB8
Specificity This antibody recognizes Human HOXB8 / HOX2D (C-term).
Purification Protein A column, followed by peptide affinity purification
Alternative Name HOXB8 / HOX2D
Background This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with colorectal cancer. Mice that have had the murine ortholog of this gene knocked out exhibit an excessive pathologic grooming behavior. This behavior is similar to the behavior of humans suffering from the obsessive-compulsive spectrum disorder trichotillomania.
Alternate names: Homeobox protein Hox-B8, Hox-2.4, Hox-2D
Molecular Weight 27574 Da
Gene ID 3218
NCBI Accession NP_076921
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09% (w/v) Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Vider, Zimber, Hirsch et al.: "Human colorectal carcinogenesis is associated with deregulation of homeobox gene expression." in: Biochemical and biophysical research communications, Vol. 232, Issue 3, pp. 742-8, 1997 (PubMed).

Fujino, Yamazaki, Largaespada et al.: "Inhibition of myeloid differentiation by Hoxa9, Hoxb8, and Meis homeobox genes." in: Experimental hematology, Vol. 29, Issue 7, pp. 856-63, 2001 (PubMed).

Knoepfler, Sykes, Pasillas et al.: "HoxB8 requires its Pbx-interaction motif to block differentiation of primary myeloid progenitors and of most cell line models of myeloid differentiation." in: Oncogene, Vol. 20, Issue 39, pp. 5440-8, 2001 (PubMed).

Greer, Capecchi: "Hoxb8 is required for normal grooming behavior in mice." in: Neuron, Vol. 33, Issue 1, pp. 23-34, 2002 (PubMed).

Kosaki, Kosaki, Suzuki et al.: "Complete mutation analysis panel of the 39 human HOX genes." in: Teratology, Vol. 65, Issue 2, pp. 50-62, 2002 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN952779
357.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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