HOXB8 antibody (N-Term)

Catalog No. ABIN2781203

The Rabbit Polyclonal anti-HOXB8 antibody is suitable to detect HOXB8 in samples from Human, Mouse, Rat, Dog, Pig, Rabbit, Cow, Horse and Sheep. It has been validated for WB.

Quick Overview for HOXB8 antibody (N-Term) (ABIN2781203)

Target: HOXB8 (Homeobox B8 (HOXB8))

Reactivity: Human, Mouse, Rat, Dog, Pig, Rabbit, Cow, Horse, Sheep

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HOXB8 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-HOXB8 Antibody

Binding Specificity: N-Term

Purpose: HOXB8 Antibody - N-terminal region

Sequence: MSSYFVNSLF SKYKTGESLR PNYYDCGFAQ DLGGRPTVVY GPSSGGSFQH

Predicted Reactivity: Cow: 79%, Dog: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Sheep: 79%

Characteristics: This is a rabbit polyclonal antibody against HOXB8. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human HOXB8

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP39583-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for HOXB8

Target: HOXB8 (Homeobox B8 (HOXB8))

Alternative Name: HOXB8

Background:

Background Information: HOXB8 is a member of the Antp homeobox family and is a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. HOXB8 functions as a sequence-specific transcription factor that is involved in development. Increased expression of this HOXB8 gene is associated with colorectal cancer. Mice that have had the murine ortholog of this gene knocked out exhibit an excessive pathologic grooming behavior. This behavior is similar to the behavior of humans suffering from the obsessive-compulsive spectrum disorder trichotillomania.This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with colorectal cancer. Mice that have had the murine ortholog of this gene knocked out exhibit an excessive pathologic grooming behavior. This behavior is similar to the behavior of humans suffering from the obsessive-compulsive spectrum disorder trichotillomania.

Gene Name: Homeobox B8

Alternative Symbols: HOX2, HOX2D, Hox-2.4

Protein Name: Homeobox protein Hox-B8

Molecular Weight: 28kDa

Gene ID: 3218

NCBI Accession: NP_076921

UniProt: P17481