Inscuteable Homolog (Drosophila) (INSC) (AA 416-446), (Middle Region) antibody

Details for Product No. ABIN952908
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Synonyms 3830422K02Rik, C730020D23, RGD1311379
AA 416-446, Middle Region
(15), (14), (14), (13), (2), (1)
(48), (14), (13)
(47), (1)
(5), (5), (5), (4), (4), (4), (1), (1), (1), (1), (1), (1), (1), (1)
Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(39), (29), (23), (9), (6), (6), (1), (1), (1)
Pubmed 4 references available
Quantity 0.4 mL
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Catalog No. ABIN952908
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Immunogen KLH conjugated synthetic peptide between 416~446 amino acids from the Central region of Human INSC
Isotype Ig
Specificity This antibody recognizes Human INSC (Center).
Purification Protein A column, followed by peptide affinity purification
Alternative Name INSC
Background In Drosophila, neuroblasts divide asymmetrically into another neuroblast at the apical side and a smaller ganglion mother cell on the basal side. Cell polarization is precisely regulated by 2 apically localized multiprotein signaling complexes that are tethered by Inscuteable, which regulates their apical localization (Izaki et al., 2006 [PubMed 16458856]).Synonyms: Protein inscuteable homolog
Molecular Weight 63469 Da
Gene ID 387755
NCBI Accession NP_001027024
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09 % (W/V) Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Vural, Oner, An et al.: "Distribution of activator of G-protein signaling 3 within the aggresomal pathway: role of specific residues in the tetratricopeptide repeat domain and differential regulation by the AGS3 binding partners Gi(alpha) and mammalian inscuteable." in: Molecular and cellular biology, Vol. 30, Issue 6, pp. 1528-40, 2010 (PubMed).

Rivadeneira, Styrkársdottir, Estrada et al.: "Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies." in: Nature genetics, Vol. 41, Issue 11, pp. 1199-206, 2009 (PubMed).

Izaki, Kamakura, Kohjima et al.: "Two forms of human Inscuteable-related protein that links Par3 to the Pins homologues LGN and AGS3." in: Biochemical and biophysical research communications, Vol. 341, Issue 4, pp. 1001-6, 2006 (PubMed).

Katoh, Katoh: "Identification and characterization of human Inscuteable gene in silico." in: International journal of molecular medicine, Vol. 11, Issue 1, pp. 111-6, 2002 (PubMed).

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