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Details for Product No. ABIN952908

Inscuteable Homolog (Drosophila) (INSC) (AA 416-446), (Middle Region) antibody

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Antigen
Synonyms 3830422K02Rik, C730020D23, RGD1311379
Epitope
»Alternatives AA 416-446, Middle Region
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Pubmed 4 references available
Catalog no. ABIN952908
Quantity 0.4 mL
Price
346.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Immunogen KLH conjugated synthetic peptide between 416~446 amino acids from the Central region of Human INSC
Specificity This antibody recognizes Human INSC (Center).
Purification Protein A column, followed by peptide affinity purification
Alternative Name INSC
Background In Drosophila, neuroblasts divide asymmetrically into another neuroblast at the apical side and a smaller ganglion mother cell on the basal side. Cell polarization is precisely regulated by 2 apically localized multiprotein signaling complexes that are tethered by Inscuteable, which regulates their apical localization (Izaki et al., 2006 [PubMed 16458856]).
Alternate names: Protein inscuteable homolog
Molecular Weight 63469 Da
Gene ID 387755
NCBI Accession NP_001027024
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09% (w/v) Sodium Azide as preservative
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Katoh, Katoh: "Identification and characterization of human Inscuteable gene in silico." in: International journal of molecular medicine, Vol. 11, Issue 1, pp. 111-6, 2002 (PubMed).

Izaki, Kamakura, Kohjima et al.: "Two forms of human Inscuteable-related protein that links Par3 to the Pins homologues LGN and AGS3." in: Biochemical and biophysical research communications, Vol. 341, Issue 4, pp. 1001-6, 2006 (PubMed).

Rivadeneira, Styrkársdottir, Estrada et al.: "Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies." in: Nature genetics, Vol. 41, Issue 11, pp. 1199-206, 2009 (PubMed).

Vural, Oner, An et al.: "Distribution of activator of G-protein signaling 3 within the aggresomal pathway: role of specific residues in the tetratricopeptide repeat domain and differential regulation by the AGS3 binding partners Gi(alpha) and mammalian inscuteable." in: Molecular and cellular biology, Vol. 30, Issue 6, pp. 1528-40, 2010 (PubMed).

Alternatives for antigen "Inscuteable Homolog (Drosophila) (INSC)", type "Antibodies"
Hosts (21)
Reactivities (21), (17), (13), (11), (11), (11)
Applications (12), (9), (6), (6), (5)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (4), (2), (2), (2), (1), (1), (1)
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