Gastric Intrinsic Factor (Vitamin B Synthesis) (GIF) (AA 188-218), (Middle Region) antibody

Details for Product No. ABIN952930
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Synonyms GIF, AV073125, IF, IFMH, INF, TCN3
AA 188-218, Middle Region
(13), (8), (6), (2), (1), (1), (1), (1), (1), (1)
(30), (2), (2), (1)
(27), (5), (1)
(2), (2), (2), (2), (2), (2)
Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(25), (16), (16), (15), (12), (7), (4), (3), (3), (2), (1), (1)
Pubmed 4 references available
Quantity 0.4 mL
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Catalog No. ABIN952930
357.50 $
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Immunogen KLH conjugated synthetic peptide between 188-218 amino acids from the Central region of Human Intrinsic factor Genename: GIF
Isotype Ig
Specificity This antibody recognizes Human Intrinsic factor (Center).
Purification Protein A column, followed by peptide affinity purification
Alternative Name Intrinsic Factor
Background This gene is a member of the cobalamin transport protein family. It encodes a glycoprotein secreted by parietal cells of the gastric mucosa and is required for adequate absorption of vitamin B12. Vitamin B12 is necessary for erythrocyte maturation and mutations in this gene may lead to congenital pernicious anemia.Synonyms: GIF, Gastric intrinsic factor, IFMH, INF
Molecular Weight 45416 Da
Gene ID 2694
NCBI Accession NP_005133
Research Area Metabolism
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09 % (W/V) Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Levine, Figueiredo, Lee et al.: "A candidate gene study of folate-associated one carbon metabolism genes and colorectal cancer risk." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 19, Issue 7, pp. 1812-21, 2010 (PubMed).

Andersen, Madsen, Storm et al.: "Structural basis for receptor recognition of vitamin-B(12)-intrinsic factor complexes." in: Nature, Vol. 464, Issue 7287, pp. 445-8, 2010 (PubMed).

Ament, Li, Sturm et al.: "Juvenile cobalamin deficiency in individuals of African ancestry is caused by a founder mutation in the intrinsic factor gene GIF." in: British journal of haematology, Vol. 144, Issue 4, pp. 622-4, 2009 (PubMed).

Remacha, Del Río, Sardà et al.: "Role of (Glu --> Arg, Q5R) mutation of the intrinsic factor in pernicious anemia and other causes of low vitamin B12." in: Annals of hematology, Vol. 87, Issue 7, pp. 599-600, 2008 (PubMed).

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