Iron-Responsive Element Binding Protein 2 (IREB2) (AA 208-238), (Middle Region) antibody

Details for Product No. ABIN952944
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Antigen
Synonyms IREB2, im:7153062, DKFZp468N047, D9Ertd85e, Irp2, ACO3, IRP2, IRP2AD, IREBP2
Epitope
AA 208-238, Middle Region
(10), (10), (5), (5), (5), (3), (2), (2), (1), (1)
Reactivity
Human
(23), (18), (5), (1), (1), (1)
Host
Rabbit
(31), (6), (4)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (1), (1), (1), (1)
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS), ELISA, Western Blotting (WB)
(41), (14), (7), (6), (5), (2), (2), (1), (1)
Pubmed 5 references available
Quantity 0.4 mL
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Catalog No. ABIN952944
357.50 $
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Immunogen KLH conjugated synthetic peptide between 208-238 amino acids from the Central region of human IREB2
Specificity This antibody recognizes Human IREB2 (Center).
Purification Protein A column, followed by peptide affinity purification
Alternative Name IREB2
Background IREB2 is a RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA.
Alternate names: IRE-BP2, IRP2, Iron regulatory protein 2, Iron-responsive element-binding protein 2
Molecular Weight 105045 Da
Gene ID 3658
NCBI Accession NP_004127
Research Area Cardiovascular
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09% (w/v) Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Salahudeen, Thompson, Ruiz et al.: "An E3 ligase possessing an iron-responsive hemerythrin domain is a regulator of iron homeostasis." in: Science (New York, N.Y.), Vol. 326, Issue 5953, pp. 722-6, 2009 (PubMed).

DeMeo, Mariani, Bhattacharya et al.: "Integration of genomic and genetic approaches implicates IREB2 as a COPD susceptibility gene." in: American journal of human genetics, Vol. 85, Issue 4, pp. 493-502, 2009 (PubMed).

Cho, Boutaoui, Klanderman et al.: "Variants in FAM13A are associated with chronic obstructive pulmonary disease." in: Nature genetics, Vol. 42, Issue 3, pp. 200-2, 2010 (PubMed).

Hansen, Xiao, Rice et al.: "Fine mapping of chromosome 15q25.1 lung cancer susceptibility in African-Americans." in: Human molecular genetics, Vol. 19, Issue 18, pp. 3652-61, 2010 (PubMed).

Ucisik-Akkaya, Davis, Do et al.: "Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection." in: Molecular human reproduction, Vol. 16, Issue 10, pp. 770-7, 2010 (PubMed).

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