anti-Lactate Dehydrogenase A antibody (LDHA) (AA 161-190)

Details for Product anti-LDHA Antibody No. ABIN953153
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Synonyms gsd11, ldh-m, ldh1, ldhm, pig19, ldha1, ldhab, LDHC, LDH-M, GSD11, LDH1, LDHM, Ldh1, Ldhm, l7R2, LDH-A, ldh-h, ldha, ldha-B, ldhbb, trg-5
AA 161-190, Middle Region
(29), (28), (13), (12), (12), (6), (6), (4), (3), (2), (2), (2), (2), (1), (1), (1), (1)
(162), (30), (23), (10), (9), (7), (1)
(119), (50), (13), (6)
This Lactate Dehydrogenase A antibody is un-conjugated
(19), (14), (11), (5), (5), (5), (1), (1), (1)
Enzyme Immunoassay (EIA), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(159), (98), (59), (36), (27), (22), (21), (16), (11), (7), (6), (6), (6), (6), (4)
Pubmed 6 references available
Quantity 0.4 mL
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Immunogen KLH conjugated synthetic peptide between 161~190 amino acids from the Central region of Human LDHA
Isotype Ig
Specificity This antibody recognizes Human LDHA (Center).
Purification Protein A column, followed by peptide affinity purification
Alternative Name LDHA (LDHA Antibody Abstract)
Background LDHA catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. The protein is found predominantly in muscle tissue and belongs to the lactate dehydrogenase family. Mutations in this gene have been linked to exertional myoglobinuria.Synonyms: Cell proliferation-inducing gene 19 protein, L-lactate dehydrogenase A chain, LDH muscle subunit, LDH-A, LDH-M, NY-REN-59, PIG19, Renal carcinoma antigen NY-REN-59
Molecular Weight 36689 Da
Gene ID 3939
NCBI Accession NP_001158887
Research Area Cancer, Metabolism, Enzymes
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09 % (W/V) Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Flow Cytometry (FACS) image for anti-Lactate Dehydrogenase A antibody (LDHA) (AA 161-190) (ABIN953153) Flow cytometry analysis of Hela cells using LDHA Antibody (Center) Cat.-No AP52459PU-...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Lactate Dehydrogenase A antibody (LDHA) (AA 161-190) (ABIN953153) Immunohistochemistry analysis in formalin-fixed and paraffin-embedded human skin tiss...
Western Blotting (WB) image for anti-Lactate Dehydrogenase A antibody (LDHA) (AA 161-190) (ABIN953153) Western blot analysis of LDHA Antibody (Center) Cat.-No AP52459PU-N in Ramos, A375 ce...
Background publications Koukourakis, Giatromanolaki, Winter et al.: "Lactate dehydrogenase 5 expression in squamous cell head and neck cancer relates to prognosis following radical or postoperative radiotherapy." in: Oncology, Vol. 77, Issue 5, pp. 285-92, 2009 (PubMed).

Zhu, Feng, Li et al.: "Detecting rare variants for complex traits using family and unrelated data." in: Genetic epidemiology, Vol. 34, Issue 2, pp. 171-87, 2010 (PubMed).

Zhuang, Scolyer, Murali et al.: "Lactate dehydrogenase 5 expression in melanoma increases with disease progression and is associated with expression of Bcl-XL and Mcl-1, but not Bcl-2 proteins." in: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, Vol. 23, Issue 1, pp. 45-53, 2010 (PubMed).

Zhao, Zhou, Liu et al.: "Upregulation of lactate dehydrogenase A by ErbB2 through heat shock factor 1 promotes breast cancer cell glycolysis and growth." in: Oncogene, Vol. 28, Issue 42, pp. 3689-701, 2009 (PubMed).

Xie, Valera, Merino et al.: "LDH-A inhibition, a therapeutic strategy for treatment of hereditary leiomyomatosis and renal cell cancer." in: Molecular cancer therapeutics, Vol. 8, Issue 3, pp. 626-35, 2009 (PubMed).

Rikova, Guo, Zeng et al.: "Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. ..." in: Cell, Vol. 131, Issue 6, pp. 1190-203, 2007 (PubMed).

Catalog No. ABIN953153
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