MAX Interactor 1 (MXI1) (AA 52-82), (Middle Region) antibody

Details for Product No. ABIN953554
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Antigen
Synonyms mxi, mad2, mxd2, xmxi1, MGC89544, MXI1, etID309773.22, fb16b12, fb55f03, wu:fb16b12, wu:fb55f03, wu:fd06a08, wu:fz74f10, ENSMUSG00000067085, Gm10197, Mad2, bHLHc11, MXI-WR, MAD2, MXD2, MXI
Epitope
AA 52-82, Middle Region
(8), (7), (2), (2), (2), (2), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(19), (12), (2), (2), (2), (2), (2), (1)
Host
Rabbit
(15), (9), (4)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB)
(24), (10), (2), (2), (2), (1), (1)
Pubmed 3 references available
Quantity 0.4 mL
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
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Catalog No. ABIN953554
357.50 $
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Immunogen Synthetic peptide - KLH conjugated - corresponding to the central region (between 52-82aa) of human MXI1.
Specificity This antibody recognizes human and mouse MXI1.
Purification Purified through a Protein A column followed by peptide affinity purification
Alternative Name MXI1
Background Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in this gene are frequently found in patients with prostate tumors. Three alternatively spliced transcripts encoding different isoforms have been described. Additional alternatively spliced transcripts may exist but the products of these transcripts have not been verified experimentally.
Alternate names: Class C basic helix-loop-helix protein 11, MAX-interacting protein 1, Max interactor 1, bHLHc11
Molecular Weight 26062 Da
Gene ID 4601
NCBI Accession NP_005953
Research Area Chromatin and Nuclear Signaling, Transcription Factors
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09% (w/v) Sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Baranzini, Wang, Gibson et al.: "Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis...." in: Human molecular genetics, Vol. 18, Issue 4, pp. 767-78, 2009 (PubMed).

Tsao, Teh, Jonasch et al.: "Inhibition of Mxi1 suppresses HIF-2alpha-dependent renal cancer tumorigenesis." in: Cancer biology & therapy, Vol. 7, Issue 10, pp. 1619-27, 2008 (PubMed).

Löfstedt, Fredlund, Noguera et al.: "HIF-1alpha induces MXI1 by alternate promoter usage in human neuroblastoma cells." in: Experimental cell research, Vol. 315, Issue 11, pp. 1924-36, 2009 (PubMed).

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