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MXI1 antibody (MAX Interactor 1) (Middle Region) Primary Antibody

MXI1 Reactivity: Cow, Dog, Guinea Pig, Human, Mouse, Rabbit, Rat, Saccharomyces cerevisiae, Zebrafish (Danio rerio) IHC, WB Host: Rabbit Polyclonal
Catalog No. ABIN2777279
$229.00
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100 μL
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  • Target
    Binding Specificity
    Middle Region
    Reactivity
    Cow, Dog, Guinea Pig, Human, Mouse, Rabbit, Rat, Saccharomyces cerevisiae, Zebrafish (Danio rerio)
    Host
    Rabbit
    Clonality
    Polyclonal
    Conjugate
    This MXI1 antibody is un-conjugated
    Application
    Immunohistochemistry (IHC), Western Blotting (WB)
    Blocking Peptide
    Blocking peptide for this product available: ABIN980399
    Sequence
    LNKAKAHIKK LEEAERKSQH QLENLEREQR FLKWRLEQLQ GPQEMERIRM
    Predicted Reactivity
    Cow: 100%, Dog: 100%, Guinea Pig: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 75%, Zebrafish: 79%
    Characteristics
    This is a rabbit polyclonal antibody against MXI1. It was validated on Western Blot and immunohistochemistry.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the middle region of human MXI1
  • Target
    Alternative Name
    MXI1 (MXI1 Antibody Abstract)
    Background
    Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The MXI1 gene encodes a transcriptional repressor protein thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in MXI1 are frequently found in patients with prostate tumors.Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in this gene are frequently found in patients with prostate tumors. Three alternatively spliced transcripts encoding different isoforms have been described. Additional alternatively spliced transcripts may exist but the products of these transcripts have not been verified experimentally.
    Alias Symbols: MAD2, MGC43220, MXD2, MXI, bHLHc11
    Protein Interaction Partner: NOTCH2NL, KRTAP10-3, KRTAP10-8, KRTAP10-5, KRTAP10-9, KRTAP10-7, KRT40, RPL23AP32, CALCOCO2, MAX, ENTPD5, UBC, APP, CDC20, BUB1B, SIN3B, SIN3A, SMC3, MYC,
    Protein Size: 295
    Molecular Weight
    26 kDa
    Gene ID
    4601
    NCBI Accession
    NM_130439, NP_569157
    UniProt
    P50539
    Pathways
    Maintenance of Protein Location
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 295 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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