NK6 Homeobox 1 (NKX6-1) (C-Term), (AA 284-314) antibody

Details for Product No. ABIN953718
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Antigen
Synonyms nkx6a, nkx6.1, NKX6.1, NKX6A, zgc:92879, Nkx6.1, Nkx61, Nkx6a
Epitope
C-Term, AA 284-314
(12), (10), (7), (6), (5), (5), (3), (2), (2), (2), (2)
Reactivity
Human, Mouse (Murine)
(48), (23), (14), (1), (1), (1), (1)
Host
Rabbit
(35), (12), (1), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(4), (3), (3), (3), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB)
(34), (20), (10), (9), (2), (2), (1)
Pubmed 4 references available
Quantity 0.4 mL
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
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Catalog No. ABIN953718
357.50 $
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Immunogen Synthetic peptide - KLH conjugated - corresponding to the C-terminal region (between 284-314aa) of human NKX6-1
Specificity This antibody recognizes NKX6-1 at C-term.
Purification Purified through a Protein A column followed by peptide affinity purification
Alternative Name NKX6-1
Background In the pancreas, NKX6-1 is required for the development of beta cells and is a potent bifunctional transcription regulator that binds to AT-rich sequences within the promoter region of target genes. [Iype et al., 2004, PubMed 15056733]
Alternate names: Homeobox protein Nkx-6.1, NKX6A
Gene ID 4825
NCBI Accession NP_006159
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09% (w/v) Sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Yokoi, Kanamori, Horikawa et al.: "Association studies of variants in the genes involved in pancreatic beta-cell function in type 2 diabetes in Japanese subjects." in: Diabetes, Vol. 55, Issue 8, pp. 2379-86, 2006 (PubMed).

Schisler, Fueger, Babu et al.: "Stimulation of human and rat islet beta-cell proliferation with retention of function by the homeodomain transcription factor Nkx6.1." in: Molecular and cellular biology, Vol. 28, Issue 10, pp. 3465-76, 2008 (PubMed).

Zhu, Xia, Yang et al.: "Alterations of gastric homeoprotein expression in Helicobacter pylori infection, incisural antralisation, and intestinal metaplasia." in: Digestive diseases and sciences, Vol. 54, Issue 5, pp. 996-1002, 2009 (PubMed).

Donelan, Koya, Li et al.: "Distinct regulation of hepatic nuclear factor 1alpha by NKX6.1 in pancreatic beta cells." in: The Journal of biological chemistry, Vol. 285, Issue 16, pp. 12181-9, 2010 (PubMed).

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