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serglycin (SRGN) (AA 118-148), (C-Term) antibody

Details for Product No. ABIN954731, Supplier: Login to see
Antigen
  • PPG
  • PRG
  • PRG1
  • Prg
  • Prg1
  • Sgc
  • Pgsg
Epitope
C-Term, AA 118-148
16
16
5
2
2
2
2
1
1
1
1
Reactivity
Human
37
8
3
1
Host
Rabbit
40
3
Clonality
Polyclonal
Conjugate
Un-conjugated
4
3
2
2
2
2
1
Application
Enzyme Immunoassay (EIA), Flow Cytometry (FACS), Western Blotting (WB)
32
27
16
7
3
2
2
2
1
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Immunogen Synthetic peptide - KLH conjugated - corresponding to the C-terminal region (between 118-148aa) of human Serglycin.
Isotype Ig
Specificity This antibody recognizes Serglycin at c-term.
Cross-Reactivity (Details) Species reactivity (tested):Human
Purification Purified through a Protein A column followed by peptide affinity purification
Alternative Name Serglycin / PRG1 (SRGN Antibody Abstract)
Background The SRGN gene encodes serglycin, a protein best known as a hematopoietic cell granule proteoglycan. Proteoglycans stored in the secretory granules of many hematopoietic cells also contain a protease-resistant peptide core, which may be important for neutralizing hydrolytic enzymes. This encoded protein was found to be associated with the macromolecular complex of granzymes and perforin, which may serve as a mediator of granule-mediated apoptosis. Two transcript variants, only one of them protein-coding, have been found for this gene.Synonyms: Hematopoetic proteoglycan core protein, Platelet proteoglycan core protein, SRGN, Secretory granule proteoglycan core protein
Gene ID 5552
NCBI Accession NP_002718
Pathways
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) Sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Flow Cytometry (FACS) image for anti-serglycin (SRGN) (AA 118-148), (C-Term) antibody (ABIN954731) Flow cytometric analysis of Hela cells (right histogram) compared to a negative contr...
Western Blotting (WB) image for anti-serglycin (SRGN) (AA 118-148), (C-Term) antibody (ABIN954731) Western blot analysis in Hela cell line lysates (35ug/lane) using Serglycin / PRG1 An...
Background publications Ma, Rudd, Edner et al.: "Sequence analysis of the SRGN, AP3B1, ARF6, and SH2D1A genes in familial hemophagocytic lymphohistiocytosis." in: Pediatric blood & cancer, Vol. 50, Issue 5, pp. 1067-9, 2008 (PubMed).

Kolset, Zernichow: "Serglycin and secretion in human monocytes." in: Glycoconjugate journal, Vol. 25, Issue 4, pp. 305-11, 2008 (PubMed).

Theocharis, Seidel, Borset et al.: "Serglycin constitutively secreted by myeloma plasma cells is a potent inhibitor of bone mineralization in vitro." in: The Journal of biological chemistry, Vol. 281, Issue 46, pp. 35116-28, 2006 (PubMed).

Wang, Yoon, Oh et al.: "Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags." in: Biochemical and biophysical research communications, Vol. 345, Issue 3, pp. 1022-32, 2006 (PubMed).

Raja, Metkar, Höning et al.: "A novel mechanism for protein delivery: granzyme B undergoes electrostatic exchange from serglycin to target cells." in: The Journal of biological chemistry, Vol. 280, Issue 21, pp. 20752-61, 2005 (PubMed).