SRGN antibody (C-Term)

Catalog No. ABIN954731

Product Details anti-SRGN Antibody

Target: SRGN (serglycin (SRGN))

Binding Specificity: AA 118-148, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SRGN antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Enzyme Immunoassay (EIA)

Specificity: This antibody recognizes Serglycin at c-term.

Cross-Reactivity (Details): Species reactivity (tested):Human

Purification: Purified through a Protein A column followed by peptide affinity purification

Immunogen: Synthetic peptide - KLH conjugated - corresponding to the C-terminal region (between 118-148aa) of human Serglycin.

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) Sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for SRGN

Target: SRGN (serglycin (SRGN))

Alternative Name: Serglycin / PRG1 (SRGN Products)

Synonyms: PPG antibody, PRG antibody, PRG1 antibody, Prg antibody, Prg1 antibody, Sgc antibody, Pgsg antibody, serglycin antibody, SRGN antibody, Srgn antibody

Background: The SRGN gene encodes serglycin, a protein best known as a hematopoietic cell granule proteoglycan. Proteoglycans stored in the secretory granules of many hematopoietic cells also contain a protease-resistant peptide core, which may be important for neutralizing hydrolytic enzymes. This encoded protein was found to be associated with the macromolecular complex of granzymes and perforin, which may serve as a mediator of granule-mediated apoptosis. Two transcript variants, only one of them protein-coding, have been found for this gene.Synonyms: Hematopoetic proteoglycan core protein, Platelet proteoglycan core protein, SRGN, Secretory granule proteoglycan core protein

Gene ID: 5552

NCBI Accession: NP_002718

Pathways: Maintenance of Protein Location