Sorting Nexin 15 (SNX15) (C-Term), (AA 222-251) antibody

Details for Product No. ABIN954886
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Synonyms SNX15, hsaf001435, snx15, MGC154249, HSAF001435, 1500032B08Rik, E130013C21Rik
C-Term, AA 222-251
(30), (14), (2), (2), (2), (1), (1), (1)
(44), (4), (2)
(23), (17), (5)
(3), (3), (3), (3), (3), (3)
Enzyme Immunoassay (EIA), Western Blotting (WB)
(44), (28), (3), (2), (1)
Pubmed 3 references available
Quantity 0.4 mL
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Catalog No. ABIN954886
357.50 $
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Immunogen Synthetic peptide - KLH conjugated - corresponding to the C-terminal region ( between 222-251aa) of human SNX15.
Isotype Ig
Specificity This antibody detects human SNX15 at C-term.
Cross-Reactivity (Details) Species reactivity (tested):Human
Purification Purified through a protein A column; followed by peptide affinity purification.
Alternative Name Sorting Nexin-15 (SNX15)
Background The SNX15 gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. Overexpression of this gene results in a decrease in the processing of insulin and hepatocyte growth factor receptors to their mature subunits. This decrease is caused by the mislocalization of furin, the endoprotease responsible for cleavage of insulin and hepatocyte growth factor receptors. This protein is involved in endosomal trafficking from the plasma membrane to recycling endosomes or the trans-Golgi network. This gene encodes two transcript variants encoding distinct isoforms.
Gene ID 29907
NCBI Accession NP_037438
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) Sodium Azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Barr, Phillips, Taylor et al.: "Overexpression of a novel sorting nexin, SNX15, affects endosome morphology and protein trafficking." in: Traffic (Copenhagen, Denmark), Vol. 1, Issue 11, pp. 904-16, 2001 (PubMed).

Venter, Adams, Myers et al.: "The sequence of the human genome. ..." in: Science (New York, N.Y.), Vol. 291, Issue 5507, pp. 1304-51, 2001 (PubMed).

Phillips, Barr, Haft et al.: "Identification and characterization of SNX15, a novel sorting nexin involved in protein trafficking." in: The Journal of biological chemistry, Vol. 276, Issue 7, pp. 5074-84, 2001 (PubMed).

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