SYNCI (N-Term), (AA 133-163) antibody

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N-Term, AA 133-163
ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Pubmed 3 references available
Catalog no. ABIN955027
Quantity 0.4 mL
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Immunogen KLH conjugated synthetic peptide between 133-163 amino acids from the N-terminal region of human SYNCI
Specificity This antibody reacts to SYNCI
Purification Affinity chromatography on Protein A
Background This gene encodes a member of the intermediate filament family which contains an N- terminal head domain, followed by a central coiled-coil region and a short C-terminal tail. The protein is highly expressed in skeletal and cardiac muscle. The protein links the dystrophin associated protein complex (DAPC) to desmin filaments in muscle and may have a structural role in striated muscle. Multiple transcript variants encoding different isoforms have been found for this gene.
Alternate names: SYNC, SYNC1, Syncoilin
Gene ID 81493
NCBI Accession NP_001155180
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS 0.09% (w/v) sodium azide
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Brown, Torelli, Ugo et al.: "Syncoilin upregulation in muscle of patients with neuromuscular disease." in: Muscle & nerve, Vol. 32, Issue 6, pp. 715-25, 2005 (PubMed).

Jordanova, Irobi, Thomas et al.: "Disrupted function and axonal distribution of mutant tyrosyl-tRNA synthetase in dominant intermediate Charcot-Marie-Tooth neuropathy." in: Nature genetics, Vol. 38, Issue 2, pp. 197-202, 2006 (PubMed).

Wakayama, Matsuzaki, Yamashita et al.: "Dysbindin, syncoilin, and beta-synemin mRNA levels in dystrophic muscles." in: The International journal of neuroscience, Vol. 120, Issue 2, pp. 144-9, 2010 (PubMed).

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