SYNCI (N-Term), (AA 133-163) antibody

Details for Product No. ABIN955027
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Antigen
Epitope
AA 133-163, N-Term
(7), (7)
Reactivity
Human
(7)
Host
Rabbit
(7)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(7), (7), (7), (4), (3)
Pubmed 3 references available
Quantity 0.4 mL
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
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Immunogen KLH conjugated synthetic peptide between 133-163 amino acids from the N-terminal region of human SYNCI
Isotype Ig
Specificity This antibody reacts to SYNCI
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Affinity chromatography on Protein A
Background This gene encodes a member of the intermediate filament family which contains an N-terminal head domain, followed by a central coiled-coil region and a short C-terminal tail. The protein is highly expressed in skeletal and cardiac muscle. The protein links the dystrophin associated protein complex (DAPC) to desmin filaments in muscle and may have a structural role in striated muscle. Multiple transcript variants encoding different isoforms have been found for this gene.Synonyms: SYNC, SYNC1, Syncoilin
Molecular Weight 55299 Da
Gene ID 81493
NCBI Accession NP_001155180
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS, 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Wakayama, Matsuzaki, Yamashita et al.: "Dysbindin, syncoilin, and beta-synemin mRNA levels in dystrophic muscles." in: The International journal of neuroscience, Vol. 120, Issue 2, pp. 144-9, 2010 (PubMed).

Jordanova, Irobi, Thomas et al.: "Disrupted function and axonal distribution of mutant tyrosyl-tRNA synthetase in dominant intermediate Charcot-Marie-Tooth neuropathy. ..." in: Nature genetics, Vol. 38, Issue 2, pp. 197-202, 2006 (PubMed).

Brown, Torelli, Ugo et al.: "Syncoilin upregulation in muscle of patients with neuromuscular disease." in: Muscle & nerve, Vol. 32, Issue 6, pp. 715-25, 2005 (PubMed).

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Catalog No. ABIN955027
357.50 $
Plus shipping costs $45.00
Quantity
Price
0.4 mL
357.50 $

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