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TLE2 antibody (Transducin-Like Enhancer of Split 2 (E(sp1) Homolog, Drosophila)) (C-Term)

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Synonyms TLE2, ESG, ESG2, GRG2, Grg2, mKIAA4188
C-Term, AA 636-665
(16), (15), (5), (3), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Human, Mouse (Murine)
(31), (18), (2)
(41), (4), (1)
This TLE2 antibody is un-conjugated
(2), (2), (2), (2), (2), (2)
Enzyme Immunoassay (EIA), Western Blotting (WB)
(43), (26), (7), (3), (2), (1), (1), (1), (1)
Pubmed 4 references available
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Quantity 0.4 mL
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Immunogen KLH conjugated synthetic peptide between 636-665 amino acids from the C-terminal region of human TLE2
Isotype Ig
Specificity This antibody detects TLE2 (C-term).
Cross-Reactivity (Details) Species reactivity (tested):Human, mouse
Purification Protein A column followed by peptide affinity purification
Alternative Name TLE2 (TLE2 Antibody Abstract)
Background TLE2 is a transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity).Synonyms: GRG2, TLE2, Transducin-like enhancer protein 2
Gene ID 7089
NCBI Accession NP_001138233
Research Area Chromatin and Nuclear Signaling, Transcription Factors
Pathways WNT Signaling
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to six months or (in aliquots) at -20 °C for longer.
Supplier Images
Western Blotting (WB) image for anti-TLE2 antibody (Transducin-Like Enhancer of Split 2 (E(sp1) Homolog, Drosophila)) (C-Term) (ABIN955231) TLE2 Antibody (C-term) western blot analysis in mouse lung tissue lysates (35 µg/lane...
Background publications He, Liu, Liang et al.: "Cellular corepressor TLE2 inhibits replication-and-transcription- activator-mediated transactivation and lytic reactivation of Kaposi's sarcoma-associated herpesvirus." in: Journal of virology, Vol. 84, Issue 4, pp. 2047-62, 2010 (PubMed).

Higa, Wu, Ye et al.: "CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation." in: Nature cell biology, Vol. 8, Issue 11, pp. 1277-83, 2006 (PubMed).

Grbavec, Lo, Liu et al.: "Groucho/transducin-like enhancer of split (TLE) family members interact with the yeast transcriptional co-repressor SSN6 and mammalian SSN6-related proteins: implications for evolutionary conservation of transcription repression mechanisms." in: The Biochemical journal, Vol. 337 ( Pt 1), pp. 13-7, 1999 (PubMed).

Howell, Whitfield: "Synthesis and secretion of growth hormone in the rat anterior pituitary. I. The intracellular pathway, its time course and energy requirements." in: Journal of cell science, Vol. 12, Issue 1, pp. 1-21, 1973 (PubMed).

Catalog No. ABIN955231
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