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Zinc Finger Protein ZIC 1 (ZIC1) (AA 5-34), (N-Term) antibody

Details for Product No. ABIN955670, Supplier: Log in to see
Antigen
  • ZIC
  • ZNF201
  • opl
Epitope
N-Term, AA 5-34
17
15
13
9
5
2
1
1
1
Reactivity
Human
59
17
13
Host
Rabbit
34
23
2
1
Clonality
Polyclonal
Conjugate
Un-conjugated
3
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
49
36
11
4
3
3
2
1
Supplier
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Immunogen KLH conjugated synthetic peptide between 5-34 amino acids from the N-terminal region of human ZIC1
Isotype Ig
Specificity This antibody detects ZIC1 (N-term).
Cross-Reactivity (Details) Species reactivity (tested):Human
Purification Protein A column followed by peptide affinity purification
Alternative Name ZIC1 (ZIC1 Antibody Abstract)
Background This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important during development. Aberrant expression of this gene is seen in medulloblastoma, a childhood brain tumor. This gene is closely linked to the gene encoding zinc finger protein of the cerebellum 4, a related family member on chromosome 3. This gene encodes a transcription factor that can bind and transactivate the apolipoprotein E gene.Synonyms: ZIC, Zinc finger protein ZIC 1, Zinc finger protein of the cerebellum 1
Gene ID 7545
NCBI Accession NP_003403
Pathways
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to six months or (in aliquots) at -20 °C for longer.
Supplier Images
Western Blotting (WB) image for anti-Zinc Finger Protein ZIC 1 (ZIC1) (AA 5-34), (N-Term) antibody (ABIN955670) ZIC1 Antibody (N-term) western blot analysis in HL-60 cell line lysates (35 µg/lane)....
Background publications Brill, Gobble, Angeles et al.: "ZIC1 overexpression is oncogenic in liposarcoma." in: Cancer research, Vol. 70, Issue 17, pp. 6891-901, 2010 (PubMed).

Wang, Jin, Wang et al.: "ZIC1 is downregulated through promoter hypermethylation in gastric cancer." in: Biochemical and biophysical research communications, Vol. 379, Issue 4, pp. 959-63, 2009 (PubMed).

Baranzini, Wang, Gibson et al.: "Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis...." in: Human molecular genetics, Vol. 18, Issue 4, pp. 767-78, 2009 (PubMed).

Arora, Dutkiewicz, Scaria et al.: "Inhibition of translation in living eukaryotic cells by an RNA G-quadruplex motif." in: RNA (New York, N.Y.), Vol. 14, Issue 7, pp. 1290-6, 2008 (PubMed).

Pourebrahim, Van Dam, Bauters et al.: "ZIC1 gene expression is controlled by DNA and histone methylation in mesenchymal proliferations." in: FEBS letters, Vol. 581, Issue 26, pp. 5122-6, 2007 (PubMed).