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Zinc Finger, MYND-Type Containing 10 (ZMYND10) (AA 328-356), (Middle Region) antibody

Details for Product No. ABIN955675, Supplier: Log in to see
Antigen
  • MGC134474
  • MGC98297
  • Blu
  • BLU
  • FLU
Epitope
AA 328-356, Middle Region
17
15
15
13
11
3
3
2
2
2
1
1
1
1
Reactivity
Human
59
5
3
Host
Rabbit
51
7
1
Clonality
Polyclonal
Conjugate
Un-conjugated
4
4
4
4
4
4
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
53
40
32
30
4
Supplier
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Immunogen KLH conjugated synthetic peptide between 328-356 amino acids from the Central region of human ZMYND10
Isotype Ig
Specificity This antibody detects ZMYND10 (Center).
Cross-Reactivity (Details) Species reactivity (tested):Human
Purification Protein A column followed by peptide affinity purification
Alternative Name ZMYND10
Background BLU is a candidate tumor suppressor gene, that spans 4.5 kb on 3p21.3. It encodes a 50 kd protein, which is commonly found in transcription repressors. It is suspected that BLU has a function in cell cycle progression. BLU is a stress-responsive gene regulated by E2F.12 It is commonly found to be downregulated in non-small cell lung cancer, esophagus squamous cell carcinoma and nasopharyngeal carcinoma (NPC).Synonyms: BLU, BLu protein, LUCA12.4, Zinc finger MYND domain-containing protein 10
Gene ID 51364
NCBI Accession NP_056980
Pathways
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to six months or (in aliquots) at -20 °C for longer.
Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Zinc Finger, MYND-Type Containing 10 (ZMYND10) (AA 328-356), (Middle Region) antibody (ABIN955675) ZMYND10 Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffi...
Western Blotting (WB) image for anti-Zinc Finger, MYND-Type Containing 10 (ZMYND10) (AA 328-356), (Middle Region) antibody (ABIN955675) ZMYND10 Antibody (Center) western blot analysis in CEM cell line lysates (35 µg/lane)...
Background publications Shao, Zhang, Zhang et al.: "High-resolution melting analysis of BLU methylation levels in gastric, colorectal, and pancreatic cancers." in: Cancer investigation, Vol. 28, Issue 6, pp. 642-8, 2010 (PubMed).

Lorente, Mueller, Urdangarín et al.: "RASSF1A, BLU, NORE1A, PTEN and MGMT expression and promoter methylation in gliomas and glioma cell lines and evidence of deregulated expression of de novo DNMTs." in: Brain pathology (Zurich, Switzerland), Vol. 19, Issue 2, pp. 279-92, 2009 (PubMed).

Muzny, Scherer, Kaul et al.: "The DNA sequence, annotation and analysis of human chromosome 3. ..." in: Nature, Vol. 440, Issue 7088, pp. 1194-8, 2006 (PubMed).

Marsit, Kim, Liu et al.: "Hypermethylation of RASSF1A and BLU tumor suppressor genes in non-small cell lung cancer: implications for tobacco smoking during adolescence." in: International journal of cancer. Journal international du cancer, Vol. 114, Issue 2, pp. 219-23, 2005 (PubMed).

Qiu, Tan, Loh et al.: "The candidate tumor suppressor gene BLU, located at the commonly deleted region 3p21.3, is an E2F-regulated, stress-responsive gene and inactivated by both epigenetic and genetic mechanisms in nasopharyngeal carcinoma." in: Oncogene, Vol. 23, Issue 27, pp. 4793-806, 2004 (PubMed).