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Details for Product No. ABIN965502

AchE (N-Term) antibody

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Antigen
Epitope
»Alternatives N-Term
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Application
»Alternatives Immunohistochemistry (IHC)
Pubmed 4 references available
Catalog no. ABIN965502
Quantity 0.1 mg
Price
288.75 $   Plus shipping costs $45.00
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Availability Will be delivered in 5 to 7 Business Days
Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human ACHE (N-terminal extended acetylcholinesterase)
Purification Purified by antigen-specific affinity chromatography.
Background ACHE(acetylcholinesterase) rapidly hydrolyzes choline released into the synapse. ACHE interacts with PRIMA1. The interaction with PRIMA1 is required to anchor it to the basal lamina of cells and organize into tetramers. ACHE is responsible for the Yt blood group system. The molecular basis of the Yt(a)=Yt1/ Yt(b)=Yt2 blood group antigens is a single variation in position 353, His-353 corresponds to Yt(a) and the rare variant with Asn-353 to Yt(b).
Application Notes ELISA, Western blotting: 1µg/ml for 2hrs.
Restrictions For Research Use only
Format Liquid
Buffer This antibody is stored in PBS, 50% glycerol
Preservative Sodium azide
Storage -20 °C
Product cited in: Shafferman, Kronman, Flashner et al.: "Mutagenesis of human acetylcholinesterase. Identification of residues involved in catalytic activity and in polypeptide folding." in: The Journal of biological chemistry, Vol. 267, Issue 25, pp. 17640-8, 1992 (PubMed).

Velan, Grosfeld, Kronman et al.: "The effect of elimination of intersubunit disulfide bonds on the activity, assembly, and secretion of recombinant human acetylcholinesterase. Expression of acetylcholinesterase Cys-580----Ala mutant." in: The Journal of biological chemistry, Vol. 266, Issue 35, pp. 23977-84, 1992 (PubMed).

Soreq, Ben-Aziz, Prody et al.: "Molecular cloning and construction of the coding region for human acetylcholinesterase reveals a G + C-rich attenuating structure." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 87, Issue 24, pp. 9688-92, 1991 (PubMed).

Meshorer, Toiber, Zurel et al.: "Combinatorial complexity of 5' alternative acetylcholinesterase transcripts and protein products." in: The Journal of biological chemistry, Vol. 279, Issue 28, pp. 29740-51, 2004 (PubMed).

Alternatives for antigen "AchE", type "Antibodies"
Hosts (29), (5), (2)
Reactivities (33), (17), (17), (1), (1), (1)
Applications (33), (17), (8), (3), (3), (3), (2), (2)
Epitopes (9), (4), (3), (2), (1), (1), (1), (1), (1), (1), (1)
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