ADAM Metallopeptidase Domain 17 (ADAM17) (Isoform 1) antibody

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Antigen
Synonyms ADAM18, CD156B, CSVP, NISBD, TACE, Tace, CD156b, adam17, si:dkey-81b15.2, adam18, cd156b, csvp, tace
Epitope
Isoform 1
(37), (21), (7), (4), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(151), (74), (69), (30), (30), (18), (2)
Host
Rabbit
(136), (12), (9), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC)
(124), (74), (26), (23), (20), (20), (12), (11), (8), (3), (2), (2), (1), (1), (1)
Pubmed 11 references available
Catalog no. ABIN965510
Quantity 0.1 mg
Price
288.75 $   Plus shipping costs $45.00
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Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human ADAM17 (a disintegrin and metalloproteinase domain 17 isoform 1 preproprotein)
Purification Purified by antigen-specific affinity chromatography.
Alternative Name ADAM17
Background The ADAM17 (a disintegrin and metalloprotease (ADAM) domain 17) is a member of the ADAM protein family. Members of this family are membraneanchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The ADAM17 functions as a tumor necrosis factor-alpha converting enzyme.It binds mitotic arrest deficient 2 protein and also plays a prominent role in the activation of the Notch signaling pathway.
Research Area Cancer, Proteolysis / Ubiquitin, Metalloprotease, Alzheimer's Disease
Application Notes ELISA, Western blotting: 1µg/ml for 2hrs.
Restrictions For Research Use only
Format Liquid
Buffer This antibody is stored in PBS, 50% glycerol
Preservative Sodium azide
Storage -20 °C
Product cited in: Díaz-Rodríguez, Montero, Esparís-Ogando et al.: "Extracellular signal-regulated kinase phosphorylates tumor necrosis factor alpha-converting enzyme at threonine 735: a potential role in regulated shedding." in: Molecular biology of the cell, Vol. 13, Issue 6, pp. 2031-44, 2002 (PubMed).

Peiretti, Deprez-Beauclair, Bonardo et al.: "Identification of SAP97 as an intracellular binding partner of TACE." in: Journal of cell science, Vol. 116, Issue Pt 10, pp. 1949-57, 2003 (PubMed).

Gschwind, Hart, Fischer et al.: "TACE cleavage of proamphiregulin regulates GPCR-induced proliferation and motility of cancer cells." in: The EMBO journal, Vol. 22, Issue 10, pp. 2411-21, 2003 (PubMed).

Shao, Ueki, Nadel: "Tumor necrosis factor alpha-converting enzyme mediates MUC5AC mucin expression in cultured human airway epithelial cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 20, pp. 11618-23, 2003 (PubMed).

Valeva, Walev, Weis et al.: "A cellular metalloproteinase activates Vibrio cholerae pro-cytolysin." in: The Journal of biological chemistry, Vol. 279, Issue 24, pp. 25143-8, 2004 (PubMed).

Solomon, Rosenblum, Gonzales et al.: "Pronounced diversity in electronic and chemical properties between the catalytic zinc sites of tumor necrosis factor-alpha-converting enzyme and matrix metalloproteinases despite their high structural similarity." in: The Journal of biological chemistry, Vol. 279, Issue 30, pp. 31646-54, 2004 (PubMed).

Allinson, Parkin, Condon et al.: "The role of ADAM10 and ADAM17 in the ectodomain shedding of angiotensin converting enzyme and the amyloid precursor protein." in: European journal of biochemistry / FEBS, Vol. 271, Issue 12, pp. 2539-47, 2004 (PubMed).

Lee, Rapti, Murphy: "Delineating the molecular basis of the inactivity of tissue inhibitor of metalloproteinase-2 against tumor necrosis factor-alpha-converting enzyme." in: The Journal of biological chemistry, Vol. 279, Issue 43, pp. 45121-9, 2004 (PubMed).

Schäfer, Marg, Gschwind et al.: "Distinct ADAM metalloproteinases regulate G protein-coupled receptor-induced cell proliferation and survival." in: The Journal of biological chemistry, Vol. 279, Issue 46, pp. 47929-38, 2004 (PubMed).

Shao, Nadel: "Dual oxidase 1-dependent MUC5AC mucin expression in cultured human airway epithelial cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 3, pp. 767-72, 2005 (PubMed).

Rabie, Strehl, Ludwig et al.: "Evidence for a role of ADAM17 (TACE) in the regulation of platelet glycoprotein V." in: The Journal of biological chemistry, Vol. 280, Issue 15, pp. 14462-8, 2005 (PubMed).

Hosts (136), (12), (9), (1)
Reactivities (151), (74), (69), (30), (30), (18), (2)
Applications (124), (74), (26), (23), (20), (20), (12), (11), (8), (3), (2), (2), (1), (1), (1)
Conjugates (4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Epitopes (37), (21), (7), (4), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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