ARL6 (N-Term) antibody

Details for Product No. ABIN965594
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Antigen
Synonyms 1110036H21Rik, ARL6, AW456149, Arf4l, Arfl4, Arl5, BBS3, RP55, 1110018H24Rik, 2210411E14Rik, zgc:101762
Epitope
N-Term
(4), (2), (2), (1), (1)
Reactivity
Human
(12), (4), (3), (2), (1), (1), (1), (1)
Host
Rabbit
(12), (4), (2)
Clonality
Polyclonal
Application
Immunohistochemistry (IHC)
(14), (10), (7), (4), (2), (1), (1), (1)
Pubmed 4 references available
Quantity 0.1 mg
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Catalog No. ABIN965594
302.50 $
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Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human ARL6 (ADP-ribosylation factorlike protein 6)
Purification Purified by antigen-specific affinity chromatography.
Background ARL6 (ADP-ribosylation factor-like protein 6) belongs to the ARF family of GTP-binding proteins. ARF proteins are important regulators of cellular traffic and are the founding members of an expanding family of homologous proteins and genomic sequences. They depart from other small GTP-binding proteins by a unique structural device that implements front-back communication from the N-terminus to the nucleotide-binding site. Studies of the mouse ortholog of this protein suggest an involvement in protein transport, membrane trafficking, or cell signaling during hematopoietic maturation.
Research Area Signaling
Application Notes ELISA, Western blotting: 1µg/ml for 2hrs.
Restrictions For Research Use only
Format Liquid
Buffer This antibody is stored in PBS, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Product cited in: Jacobs, Schilf, Fliegert et al.: "ADP-ribosylation factor (ARF)-like 4, 6, and 7 represent a subgroup of the ARF family characterization by rapid nucleotide exchange and a nuclear localization signal." in: FEBS letters, Vol. 456, Issue 3, pp. 384-8, 1999 (PubMed).

Ingley, Williams, Walker et al.: "A novel ADP-ribosylation like factor (ARL-6), interacts with the protein-conducting channel SEC61beta subunit." in: FEBS letters, Vol. 459, Issue 1, pp. 69-74, 1999 (PubMed).

Chiang, Nishimura, Searby et al.: "Comparative genomic analysis identifies an ADP-ribosylation factor-like gene as the cause of Bardet-Biedl syndrome (BBS3)." in: American journal of human genetics, Vol. 75, Issue 3, pp. 475-84, 2004 (PubMed).

Fan, Esmail, Ansley et al.: "Mutations in a member of the Ras superfamily of small GTP-binding proteins causes Bardet-Biedl syndrome." in: Nature genetics, Vol. 36, Issue 9, pp. 989-93, 2004 (PubMed).

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