ARL6 antibody (AA 1-186)

Catalog No. ABIN7143513

Product Details anti-ARL6 Antibody

Target: ARL6 (ADP Ribosylation Factor Like GTPase 6 (ARL6))

Binding Specificity: AA 1-186

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ARL6 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human ADP-ribosylation factor-like protein 6 protein (1-186AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for ARL6

Target: ARL6 (ADP Ribosylation Factor Like GTPase 6 (ARL6))

Alternative Name: ARL6 (ARL6 Products)

Synonyms: BBS3 antibody, RP55 antibody, 1110018H24Rik antibody, 2210411E14Rik antibody, zgc:101762 antibody, arl6 antibody, ADP ribosylation factor like GTPase 6 antibody, ADP-ribosylation factor-like 6 antibody, ADP-ribosylation factor like GTPase 6 antibody, ADP-ribosylation factor-like protein 6 antibody, ADP ribosylation factor like GTPase 6 L homeolog antibody, ARL6 antibody, Arl6 antibody, arl6 antibody, arl-6 antibody, arl6.L antibody

Background:

Background: Involved in membrane protein trafficking at the base of the ciliary organelle. Mediates recruitment onto plasma membrane of the BBSome complex which would constitute a coat complex required for sorting of specific membrane proteins to the primary cilia (PubMed:20603001). Together with BBS1, is necessary for correct trafficking of PKD1 to primary cilia (By similarity). Together with the BBSome complex and LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation (PubMed:22072986). May regulate cilia assembly and disassembly and subsequent ciliary signaling events such as the Wnt signaling cascade (PubMed:20207729). Isoform 2 may be required for proper retinal function and organization (By similarity).

Aliases: ADP ribosylation factor like 6 antibody, ADP ribosylation factor like protein 6 antibody, ADP-ribosylation factor-like protein 6 antibody, Arl6 antibody, ARL6_HUMAN antibody, Bardet Biedl syndrome 3 protein antibody, Bardet-Biedl syndrome 3 protein antibody, BBS3 antibody, MGC32934 antibody

UniProt: Q9H0F7