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B-Cell Translocation Gene 1, Anti-Proliferative (BTG1) (N-Term) antibody

Details for Product No. ABIN965706, Supplier: Log in to see
Antigen
  • btg1
  • AI426953
  • AW546738
Epitope
N-Term
16
13
8
2
1
Reactivity
Human, Mouse (Murine), Rat (Rattus), Chicken
50
24
20
Host
Rabbit
42
8
Clonality
Polyclonal
Conjugate
Un-conjugated
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC)
26
22
21
11
7
3
2
1
Supplier
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Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human BTG1(B-cell translocation gene 1 protein)
Purification Purified by antigen-specific affinity chromatography.
Alternative Name BTG1 (BTG1 Antibody Abstract)
Background BTG1(B-cell translocation gene 1 protein) is an anti-proliferative protein. Its expression is associated with the early G1 phase of the cell cycle. A chromosomal aberration involving BTG1 may be a cause of a form of B-cell chronic lymphocytic leukemia. BTG1 expression is maximal in the G0/G1 phases of the cell cycle and downregulated when cells progressed through G1. GTG1 negatively regulates cell proliferation. BTG1 is a novel important coactivator involved in the regulation of myoblast differentiation. BTG1 may play an important role in the process of angiogenesis. Antiproliferative proteins of the BTG/Tob family are degraded by the ubiquitin-proteasome system. The C-terminal regions are necessary and sufficient to control the stabilities of BTG1, BTG2, Tob, and Tob2 proteins.
Research Area Cardiovascular, Atherosclerosis, Transcription Factors
Pathways
Application Notes ELISA, Western blotting: 1µg/ml for 2hrs.
Restrictions For Research Use only
Format Liquid
Buffer This antibody is stored in PBS, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Background publications Busson, Carazo, Seyer et al.: "Coactivation of nuclear receptors and myogenic factors induces the major BTG1 influence on muscle differentiation." in: Oncogene, Vol. 24, Issue 10, pp. 1698-710, 2005 (PubMed).

Bakker, Blázquez-Domingo, Kolbus et al.: "FoxO3a regulates erythroid differentiation and induces BTG1, an activator of protein arginine methyl transferase 1." in: The Journal of cell biology, Vol. 164, Issue 2, pp. 175-84, 2004 (PubMed).

Sasajima, Nakagawa, Yokosawa: "Antiproliferative proteins of the BTG/Tob family are degraded by the ubiquitin-proteasome system." in: European journal of biochemistry / FEBS, Vol. 269, Issue 14, pp. 3596-604, 2002 (PubMed).

Rodier, Rochard, Berthet et al.: "Identification of functional domains involved in BTG1 cell localization." in: Oncogene, Vol. 20, Issue 21, pp. 2691-703, 2001 (PubMed).

Bogdan, Adams-Burton, Pedicord et al.: "Human carbon catabolite repressor protein (CCR4)-associative factor 1: cloning, expression and characterization of its interaction with the B-cell translocation protein BTG1." in: The Biochemical journal, Vol. 336 ( Pt 2), pp. 471-81, 1999 (PubMed).

Corjay, Kearney, Munzer et al.: "Antiproliferative gene BTG1 is highly expressed in apoptotic cells in macrophage-rich areas of advanced lesions in Watanabe heritable hyperlipidemic rabbit and human." in: Laboratory investigation; a journal of technical methods and pathology, Vol. 78, Issue 7, pp. 847-58, 1998 (PubMed).

Rouault, Rimokh, Tessa et al.: "BTG1, a member of a new family of antiproliferative genes." in: The EMBO journal, Vol. 11, Issue 4, pp. 1663-70, 1992 (PubMed).