B-Cell Translocation Gene 1, Anti-Proliferative (BTG1) (N-Term) antibody

Antigen: B-Cell Translocation Gene 1, Anti-Proliferative (BTG1)

Synonyms: btg1

Binding Site: N-Term

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human, Mouse (Murine), Rat (Rattus), Chicken

Conjugate: Un-conjugated

Application: Immunohistochemistry (IHC)

Catalog no.: ABIN965706

Additional Information

Alternative name: BTG1

Immunogen: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human BTG1(B-cell translocation gene 1 protein)

Description: BTG1(B-cell translocation gene 1 protein) is an anti-proliferative protein. Its expression is associated with the early G1 phase of the cell cycle. A chromosomal aberration involving BTG1 may be a cause of a form of B-cell chronic lymphocytic leukemia. BTG1 expression is maximal in the G0/G1 phases of the cell cycle and downregulated when cells progressed through G1. GTG1 negatively regulates cell proliferation. BTG1 is a novel important coactivator involved in the regulation of myoblast differentiation. BTG1 may play an important role in the process of angiogenesis. Antiproliferative proteins of the BTG/Tob family are degraded by the ubiquitin-proteasome system. The C-terminal regions are necessary and sufficient to control the stabilities of BTG1, BTG2, Tob, and Tob2 proteins.

Application Details

Application Notes: ELISA, Western blotting: 1µg/ml for 2hrs.

Purification: Purified by antigen-specific affinity chromatography.

Buffer: This antibody is stored in PBS, 50% glycerol

Preservative: 0.01% Sodium Azide

Storage: Store at -20°C.

Research Area: Cardiovascular, Atherosclerosis, Transcription Factors

Restrictions: For Research Use only

Publications

Product: Rouault, Rimokh, Tessa et al.: "BTG1, a member of a new family of antiproliferative genes." in: The EMBO journal, Vol. 11, Issue 4, pp. 1663-70, 1992 (PubMed).

Corjay, Kearney, Munzer et al.: "Antiproliferative gene BTG1 is highly expressed in apoptotic cells in macrophage-rich areas of advanced lesions in Watanabe heritable hyperlipidemic rabbit and human." in: Laboratory investigation; a journal of technical methods and pathology, Vol. 78, Issue 7, pp. 847-58, 1998 (PubMed).

Rodier, Rochard, Berthet et al.: "Identification of functional domains involved in BTG1 cell localization." in: Oncogene, Vol. 20, Issue 21, pp. 2691-703, 2001 (PubMed).

Sasajima, Nakagawa, Yokosawa: "Antiproliferative proteins of the BTG/Tob family are degraded by the ubiquitin-proteasome system." in: European journal of biochemistry / FEBS, Vol. 269, Issue 14, pp. 3596-604, 2002 (PubMed).

Bakker, Blázquez-Domingo, Kolbus et al.: "FoxO3a regulates erythroid differentiation and induces BTG1, an activator of protein arginine methyl transferase 1." in: The Journal of cell biology, Vol. 164, Issue 2, pp. 175-84, 2004 (PubMed).