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B-Cell Translocation Gene 1, Anti-Proliferative (BTG1) (N-Term) antibody

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Synonyms btg1, AI426953, AW546738
(16), (13), (8), (2), (1)
Human, Mouse (Murine), Rat (Rattus), Chicken
(50), (24), (20)
(42), (8)
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Immunohistochemistry (IHC)
(26), (22), (21), (11), (7), (3), (2), (1)
Pubmed 7 references available
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Quantity 0.1 mg
Shipping to United States ( )
Availability Will be delivered in 5 to 7 Business Days
Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human BTG1(B-cell translocation gene 1 protein)
Purification Purified by antigen-specific affinity chromatography.
Alternative Name BTG1 (BTG1 Antibody Abstract)
Background BTG1(B-cell translocation gene 1 protein) is an anti-proliferative protein. Its expression is associated with the early G1 phase of the cell cycle. A chromosomal aberration involving BTG1 may be a cause of a form of B-cell chronic lymphocytic leukemia. BTG1 expression is maximal in the G0/G1 phases of the cell cycle and downregulated when cells progressed through G1. GTG1 negatively regulates cell proliferation. BTG1 is a novel important coactivator involved in the regulation of myoblast differentiation. BTG1 may play an important role in the process of angiogenesis. Antiproliferative proteins of the BTG/Tob family are degraded by the ubiquitin-proteasome system. The C-terminal regions are necessary and sufficient to control the stabilities of BTG1, BTG2, Tob, and Tob2 proteins.
Research Area Cardiovascular, Atherosclerosis, Transcription Factors
Application Notes ELISA, Western blotting: 1µg/ml for 2hrs.
Restrictions For Research Use only
Format Liquid
Buffer This antibody is stored in PBS, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Background publications Busson, Carazo, Seyer et al.: "Coactivation of nuclear receptors and myogenic factors induces the major BTG1 influence on muscle differentiation." in: Oncogene, Vol. 24, Issue 10, pp. 1698-710, 2005 (PubMed).

Bakker, Blázquez-Domingo, Kolbus et al.: "FoxO3a regulates erythroid differentiation and induces BTG1, an activator of protein arginine methyl transferase 1." in: The Journal of cell biology, Vol. 164, Issue 2, pp. 175-84, 2004 (PubMed).

Sasajima, Nakagawa, Yokosawa: "Antiproliferative proteins of the BTG/Tob family are degraded by the ubiquitin-proteasome system." in: European journal of biochemistry / FEBS, Vol. 269, Issue 14, pp. 3596-604, 2002 (PubMed).

Rodier, Rochard, Berthet et al.: "Identification of functional domains involved in BTG1 cell localization." in: Oncogene, Vol. 20, Issue 21, pp. 2691-703, 2001 (PubMed).

Bogdan, Adams-Burton, Pedicord et al.: "Human carbon catabolite repressor protein (CCR4)-associative factor 1: cloning, expression and characterization of its interaction with the B-cell translocation protein BTG1." in: The Biochemical journal, Vol. 336 ( Pt 2), pp. 471-81, 1999 (PubMed).

Corjay, Kearney, Munzer et al.: "Antiproliferative gene BTG1 is highly expressed in apoptotic cells in macrophage-rich areas of advanced lesions in Watanabe heritable hyperlipidemic rabbit and human." in: Laboratory investigation; a journal of technical methods and pathology, Vol. 78, Issue 7, pp. 847-58, 1998 (PubMed).

Rouault, Rimokh, Tessa et al.: "BTG1, a member of a new family of antiproliferative genes." in: The EMBO journal, Vol. 11, Issue 4, pp. 1663-70, 1992 (PubMed).

Catalog No. ABIN965706
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