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Details for Product No. ABIN965976

DNA Cross-Link Repair 1C (DCLRE1C) antibody

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Antigen
Synonyms A-SCID, DCLREC1C, RS-SCID, SCIDA, SNM1C, hSNM1C, 9930121L06Rik, AI661365, Art, Snm1l, artemis, nuclease
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Application
»Alternatives Immunohistochemistry (IHC)
Pubmed 7 references available
Catalog no. ABIN965976
Quantity 0.1 mg
Price
452.38 $   Plus shipping costs $45.00
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Availability Will be delivered in 5 to 7 Business Days
Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-residues of human DCLRE1C (DNA cross-link repair 1C protein)
Alternative Name DCLRE1C
Background DCLRE1C (DNA cross-link repair 1C protein) is required for V(D)J recombination, the process by which exons encoding the antigen-binding domains of immunoglobulins and T-cell receptor proteins are assembled from individual V, (D), and J gene segments. V(D)J recombination is initiated by the lymphoid specific RAG endonuclease complex, which generates site specific DNA double strand breaks (DSBs). These DSBs present two types of DNA end structures: hairpin sealed coding ends and phosphorylated blunt signal ends. These ends are independently repaired by the non homologous end joining (NHEJ) pathway to form coding and signal joints respectively. This protein exhibits single-strand specific 5'-3' exonuclease activity in isolation and acquires endonucleolytic activity on 5' and 3' hairpins and overhangs when in a complex with PRKDC. The latter activity is required specifically for the resolution of closed hairpins prior to the formation of the coding joint. May also be required for the repair of complex DSBs induced by ionizing radiation, which require substantial end-processing prior to religation by NHEJ.
Synonyms: ARTEMIS, ASCID, SCIDA, SNM1C
Restrictions For Research Use only
Product cited in: Moshous, Callebaut, de Chasseval et al.: "Artemis, a novel DNA double-strand break repair/V(D)J recombination protein, is mutated in human severe combined immune deficiency." in: Cell, Vol. 105, Issue 2, pp. 177-86, 2001 (PubMed).

Ma, Pannicke, Schwarz et al.: "Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination." in: Cell, Vol. 108, Issue 6, pp. 781-94, 2002 (PubMed).

Callebaut, Moshous, Mornon et al.: "Metallo-beta-lactamase fold within nucleic acids processing enzymes: the beta-CASP family." in: Nucleic acids research, Vol. 30, Issue 16, pp. 3592-601, 2002 (PubMed).

Poinsignon, Moshous, Callebaut et al.: "The metallo-beta-lactamase/beta-CASP domain of Artemis constitutes the catalytic core for V(D)J recombination." in: The Journal of experimental medicine, Vol. 199, Issue 3, pp. 315-21, 2004 (PubMed).

Pannicke, Ma, Hopfner et al.: "Functional and biochemical dissection of the structure-specific nuclease ARTEMIS." in: The EMBO journal, Vol. 23, Issue 9, pp. 1987-97, 2004 (PubMed).

Poinsignon, de Chasseval, Soubeyrand et al.: "Phosphorylation of Artemis following irradiation-induced DNA damage." in: European journal of immunology, Vol. 34, Issue 11, pp. 3146-55, 2004 (PubMed).

Ma, Lu, Tippin et al.: "A biochemically defined system for mammalian nonhomologous DNA end joining." in: Molecular cell, Vol. 16, Issue 5, pp. 701-13, 2004 (PubMed).

Alternatives for antigen "DNA Cross-Link Repair 1C (DCLRE1C)", type "Antibodies"
Hosts (37), (8)
Reactivities (44), (16), (5), (1), (1)
Applications (40), (26), (14), (13), (8), (1), (1)
Epitopes (7), (6), (5), (4), (3), (3), (3), (1), (1), (1)
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