Disrupted in Schizophrenia 1 (DISC1) (C-Term) antibody

Antigen: Disrupted in Schizophrenia 1 (DISC1)

Synonyms: SCZD9, C1orf136, FLJ13381, FLJ21640, FLJ25311, FLJ41105, KIAA0457, DISC1

Binding Site: C-Term

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Immunohistochemistry (IHC)

Catalog no.: ABIN965998

Additional Information

Alternative name: DISC1 (Disrupted in schizophrenia 1 protein)

Immunogen: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human DISC1(Disrupted in schizophrenia 1 protein)

Description: DISC1 (Disrupted in schizophrenia 1 protein) is a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. DISC1 is involved in neurite outgrowth and cortical development through its interaction with other proteins. DISC1 interacts with tubulin alpha, ACTN2, ANKHD1, ATF4, ATF5, CEP63, EIF3S3, MAP1A, NDEL1, PAFAH1B1, RANBP9, SPTBN4, SYNE1 and TRAF3IP1. The interaction with microtubules may be mediated in part by TRAF3IP1. A chromosomal aberration involving DISC1 segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Translocation t(1,11)(q42.1,q14.3). The truncated DISC1 protein produced by this translocation is unable to interact with ATF4, ATF5 and NDEL1.

Application Details

Application Notes: ELISA, Western blotting: 1µg/ml for 2hrs.

Purification: Purified by antigen-specific affinity chromatography.

Buffer: This antibody is stored in PBS, 50% glycerol

Preservative: 0.01% Sodium Azide

Storage: Store at -20°C.

Restrictions: For Research Use only

Publications

Product: Seki, Ohira, Nagase et al.: "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain." in: DNA research : an international journal for rapid publication of reports on genes and genomes, Vol. 4, Issue 5, pp. 345-9, 1998 (PubMed).

Millar, Wilson-Annan, Anderson et al.: "Disruption of two novel genes by a translocation co-segregating with schizophrenia." in: Human molecular genetics, Vol. 9, Issue 9, pp. 1415-23, 2000 (PubMed).

Ozeki, Tomoda, Kleiderlein et al.: "Disrupted-in-Schizophrenia-1 (DISC-1): mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 1, pp. 289-94, 2003 (PubMed).

Taylor, Devon, Millar et al.: "Evolutionary constraints on the Disrupted in Schizophrenia locus." in: Genomics, Vol. 81, Issue 1, pp. 67-77, 2003 (PubMed).

Morris, Kandpal, Ma et al.: "DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation." in: Human molecular genetics, Vol. 12, Issue 13, pp. 1591-608, 2003 (PubMed).