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Gonadotropin-Releasing Hormone Receptor (GNRHR) (Extracellular Domain), (AA 1-29) antibody

Details for Product No. ABIN966217
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Antigen
Synonyms
GNRHR, gnrhr, AKHR, Akhr, BEST:GH19447, CG11325, DAKHR, DAKHR-1, DGRHR, Dmel\\CG11325, GRHR/CG11325, GnRHR, akhr, GNRHR1/III, GNRHR2, GNRHR1, xgnrhr, gnrhr3/ii, gnrh-r, GH1, Lhrhr, GRHR, HH7, LHRHR, L ... show more
GNRHR, gnrhr, AKHR, Akhr, BEST:GH19447, CG11325, DAKHR, DAKHR-1, DGRHR, Dmel\\CG11325, GRHR/CG11325, GnRHR, akhr, GNRHR1/III, GNRHR2, GNRHR1, xgnrhr, gnrhr3/ii, gnrh-r, GH1, Lhrhr, GRHR, HH7, LHRHR, LRHR show less
Epitope
Extracellular Domain, AA 1-29
(15), (11), (7), (5), (4), (2), (2), (2), (2), (1), (1), (1)
Reactivity
Human
(71), (22), (16), (13), (12), (12), (1), (1)
Host
Mouse
(46), (24), (5)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Flow Cytometry (FACS), Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))
(46), (33), (16), (15), (11), (10), (10), (9), (2), (2), (1)
Pubmed 5 references available
Quantity 0.5 mL
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Catalog No. ABIN966217
192.50 $
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Immunogen BSA-conjugated peptide (amino acids1-29) of human GnrH receptor extracellular domain.
Clone B470
Isotype IgG1
Specificity This antibody reacts with GnrH receptors found in the anterior pituitary. GnrH functions as a stimulator of gonadotrophs to release luteinizing hormone (LH) and follicle stimulating hormone (FSH).
Purification Concentrated.
Alternative Name GnRH Receptor
Gene ID 2798
Application Notes Immunohistochemistry: 1:50-1:100.
ELISA: 1:1000-1:3000.
Flow cytometry: 1:150-1:300.
Western Blot 1:200-1:500.
Staining Procedure: This antibody can be used on frozen tissue sections. The antibody may be used at a dilution of 1:50-1:100 in IHC. The optimal conditions should be determined by the individual laboratory.
Comment

Recommended Positive Control: Pituitary Tissue.

Restrictions For Research Use only
Format Liquid
Concentration 0.3 mg/ml.
Buffer 20 mM tris-borate, 150 mM Sodium Chloride, dialyzed media RPMI 1640/D-MEM containing fetal bovine serum, BMC-6 carrier polysaccharides, carrier protein, pH 7.5
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Product cited in: Karande, Rajeshwari, Schol et al.: "Establishment of immunological probes to study human gonadotropin-releasing hormone receptors." in: Molecular and cellular endocrinology, Vol. 114, Issue 1-2, pp. 51-6, 1996 (PubMed).

Fraser, Sellar, Illingworth et al.: "GnRH receptor mRNA expression by in-situ hybridization in the primate pituitary and ovary." in: Molecular human reproduction, Vol. 2, Issue 2, pp. 117-21, 1997 (PubMed).

Jennes, Eyigor, Janovick et al.: "Brain gonadotropin releasing hormone receptors: localization and regulation." in: Recent progress in hormone research, Vol. 52, pp. 475-90; discussion 490-1, 1997 (PubMed).

Arora, Cheng, Catt: "Mutations of the conserved DRS motif in the second intracellular loop of the gonadotropin-releasing hormone receptor affect expression, activation, and internalization." in: Molecular endocrinology (Baltimore, Md.), Vol. 11, Issue 9, pp. 1203-12, 1997 (PubMed).

Grosse, Schöneberg, Schultz et al.: "Inhibition of gonadotropin-releasing hormone receptor signaling by expression of a splice variant of the human receptor." in: Molecular endocrinology (Baltimore, Md.), Vol. 11, Issue 9, pp. 1305-18, 1997 (PubMed).

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