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V-Erb-B2 erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/glioblastoma Derived Oncogene Homolog (Avian) (ERBB2) antibody

Antigen

V-Erb-B2 erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/glioblastoma Derived Oncogene Homolog (Avian) (ERBB2)
Synonyms Neu, HER2, HER-2, c-neu, Erbb-2, c-erbB2, mKIAA3023, NEU, NGL, TKR1, CD340, HER-2/neu
Clonality Polyclonal
Host
Alternatives

Rabbit
Reactivity
Alternatives

Human, Mouse (Murine), Rat (Rattus)
Conjugate
Alternatives Un-conjugated
Application
Alternatives Immunohistochemistry (IHC)
6 references available
Catalog no. ABIN966279
Quantity 100ug  (100ug/100ul.)  (Variants)
Price 385.00 $   Plus shipping costs $45.00
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Alternative name HER2
Immunogen The antiserum was produced against synthesized non-phosphopeptide derived from human HER2 around the phosphorylation site of tyrosine 877 (T-E-YP-H-A).
Specificity HER2 (Ab-877) antibody detects endogenous levels of total HER2 protein.

Application Details
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Application Notes WB: 1:500~1:1000
IHC: 1:50~1:100.
Concentration 100ug/100ul.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative 0.02% Sodium Azide
Storage Store at -20°C/1 year.
Restrictions For Research Use only

Publications
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Product Qian, LeVea, Freeman et al.: "Heterodimerization of epidermal growth factor receptor and wild-type or kinase-deficient Neu: a mechanism of interreceptor kinase activation and transphosphorylation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, Issue 4, pp. 1500-4, 1994 (PubMed).

Kwon, Bhattacharyya, Alberta et al.: "Activation of ErbB2 during wallerian degeneration of sciatic nerve." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 17, Issue 21, pp. 8293-9, 1997 (PubMed).

Muthuswamy, Gilman, Brugge: "Controlled dimerization of ErbB receptors provides evidence for differential signaling by homo- and heterodimers." in: Molecular and cellular biology, Vol. 19, Issue 10, pp. 6845-57, 2000 (PubMed).

Zhang, Wong-Riley: "Synthesis and degradation of cytochrome oxidase subunit mRNAs in neurons: differential bigenomic regulation by neuronal activity." in: Journal of neuroscience research, Vol. 60, Issue 3, pp. 338-44, 2000 (PubMed).

Klapper, Waterman, Sela et al.: "Tumor-inhibitory antibodies to HER-2/ErbB-2 may act by recruiting c-Cbl and enhancing ubiquitination of HER-2." in: Cancer research, Vol. 60, Issue 13, pp. 3384-8, 2000 (PubMed).

Dittadi, Gion: "More about: prognostic importance of low c-erbB2 expression in breast tumors." in: Journal of the National Cancer Institute, Vol. 92, Issue 17, pp. 1443-4, 2000 (PubMed).

Alternatives
Application Details Publications Variants back to top

Alternatives for antigen "V-Erb-B2 erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/glioblastoma Derived Oncogene Homolog (Avian) (ERBB2)", type "Antibodies"
Hosts Rabbit (251), Mouse (147), Chicken (8), Rat (7), Sheep (4), Goat (1)
Reactivities Human (402), Mouse (Murine) (127), Rat (Rattus) (127), Dog (Canine) (41), Horse (Equine) (33), Cow (Bovine) (11), Pig (Porcine) (10), Chicken (6), Guinea Pig (5), Monkey (5), Sheep (Ovine) (5), Cat (Feline) (1)
Applications Western Blotting (WB) (250), Immunofluorescence (IF) (142), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (124), Immunohistochemistry (IHC) (119), ELISA (95), Immunoprecipitation (IP) (91), Flow Cytometry (FACS) (28), Immunocytochemistry (ICC) (26), Immunohistochemistry (Fixed) (IHC (fx)) (23), Immunohistochemistry (Frozen Sections) (IHC (fro)) (15), Electrophoretic Mobility-Shift Assay (EMSA) (11), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (8), Enzyme Immunoassay (EIA) (5), Functional Studies (Func) (4), Dot Blot (DB) (2), Cellular Assay (CA) (1), Dot Blot (Dot) (1), Fluorescence Microscopy (FM) (1), Immunoassay (IA) (1), Immunoelectron Microscopy (IEM) (1), Immunostaining (ISt) (1), Radioimmunoassay (RIA) (1)
Conjugates Biotin (16), Alexa Fluor 350 (6), Alexa Fluor 488 (6), Alexa Fluor 555 (6), Alexa Fluor 647 (6), PE,Cy5.5 (6), FITC (2), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy7 (1)
Epitopes pTyr1248 (18), C-Term (17), pTyr877 (16), Extracellular Domain (13), Internal Region (11), pTyr1112 (8), Tyr1248 (6), pTyr1221, pTyr1222 (6), Cytoplasmic Domain (5), pTyr1222,pTyr1221 (5), pTyr686 (4), AA 750-987 (3), N-Term (3), pThr686 (3), pTyr1112,C-Term (3), pTyr1221,pTyr1222 (3), AA 153-433 (2), Tyr1221,Tyr1222 (2), Tyr877 (2), AA 1238-1255 (1), AA 1242-1255,C-Term (1), AA 1243-1255 (1), AA 146-195 (1), AA 23-419 (1), AA 23-652 (1), AA 968-1020 (1), Extracellular (1), Ser1112 (1), Ser877 (1), Tyr1196 (1), Tyr1221, Tyr1222 (1), Tyr1222 (1), pSer1108 (1), pSer486,pSer498,pSer632 (1), pThr1221, pThr1222 (1), pTyr1139 (1), pTyr1221 (1), pTyr1222 (1)